RESEARCH PAPER INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL ANALYSIS (2017, VOl. 01(02) WWW.IJPPA.COM ISSN: 2394-1618 Page numbers:79 -84 “FORMULATION AND EVALUATION OF CURCUMIN LOADED TOPICAL GEL J Adlin Jino Nesalin*, T Pavithra, A Pallavi, BL Umesh , T Tamizh Mani *Department of Pharamaceutics, Bharathi College of Pharmacy, Bharathinagar, Maddur Taluk, Mandya District, Karnataka, India. ABSTRACT The present study was aimed to develop topical gel of Curcumin which enhances the bioavailability & permeation with the help of combination of polymers which will be useful in further drug delivery. Polymers plays major role in various characterization parameters of topical gel such as in vitro release and rheological properties KEYWORDS: CURCUMIN, TOPICAL GEL,CARBAPOL,CARCINOGENIC ACTIVITY Corresponding Author: J Adlin Jino Nesalin, Department of Pharamaceutics, Bharathi College of Pharmacy, Bharathinagar, Maddur Taluk, Mandya District, Karnataka, India. E –Mail: adlinjino@gmail.com INTRODUCTION Neoplasm/ tumour is defined as growth/mass of abnormal tissue formed due to excess and uncoordinated cell proliferation. Characteristic abnormal uncontrolled cell devision, dedifferentiation and loss of function , ability to spread to other parts of the body ,metastasis. There have been concerns related to the conventional topical dosage forms such as lotions, creams, ointments and powder in terms of drug diffusion or release from the vehicle and delivery through the skin. Creams and Lotions often provide poor bioavailability of the drug because they are rapidly cleared from the skin and poorly release the drug from base. Non hydrophilic ointments are oleaginous, greasy and are non convenient to patients and also medicated powders for topical application have short residence time on the skin. Gels are semisolid systems in which the movement of the dispersion medium is restricted by interlacing three dimensional network of particles or solvated macromolecules of dispersed phase. The increased viscosity caused by interlacing and consequently internal friction is responsible for the semisolid state. Also a gel may consist of twisted matted strands often tied together by stronger types of Vander Waals Forces to form crystalline and amorphous regions throughout the system. 1 The use of gel as a delivery system can increase the residence time of drugs on the skin and consequently enhance