1 Supporting Information Ultrasensitive Simultaneous Detection of Multiplex Disease-Related Nucleic Acids Using Double-Enhanced Surface-Enhanced Raman Scattering Nanosensors Ruiyan Guo, † , ∥ Fangfei Yin, † , ∥ , ‡ Yudie Sun, † Lan Mi, † Lin Shi, † Zhijin Tian † and Tao Li *, † † Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. * E-mail: tlitao@ustc.edu.cn ∥ R.G. and F.Y. contributed equally to the research as co-first authors. ‡ Present Address: Division of Physical Biology and Bioimaging Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China