Akter et al Journal of Drug Delivery & Therapeutics. 2021; 11(3-s):1-6 ISSN: 2250-1177 [1] CODEN (USA): JDDTAO Available online on 15.06.2021 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-21, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use(CC By-NC), provided the original work is properly cited Open Access Full Text Article Short Communication Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Tramadol Hydrochloride Jesmin Akter 1 , Nusrat Ahmed 2 *, Sabrina Rahman Archie 2 1 Department of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh 2 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh Article Info: ___________________________________________ Article History: Received 19 April 2021 Reviewed 23 May 2021 Accepted 28 May 2021 Published 15 June 2021 ___________________________________________ Cite this article as: Akter J, Ahmed N, Archie SR, Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Tramadol Hydrochloride, Journal of Drug Delivery and Therapeutics. 2021; 11(3-S):1-6 DOI: http://dx.doi.org/10.22270/jddt.v11i3-S.4875 Abstract ______________________________________________________________________________________________________ Since orally disintegrating tablets (ODTs) of tramadol hydrochloride are not available in the market, so an attempt has been taken to formulate and evaluate ODT preparation of tramadol hydrochloride. In this present work, direct compression was the technique used for preparing ODT using superdisintegrants like croscarmellose sodium, sodium starch glycolate and crospovidone at different concentrations. Prepared formulations were evaluated for various quality parameters- angle of repose, Carr’s index, Hausner ratio, weight variation, friability, hardness, drug content, dispersion time, wetting time and in- vitro dissolution. The angle of repose data indicated that the flow property of all the formulations was good to excellent. Comparing with the specifications, the results of Carr's index (%) and Hausner’s ratio indicated that the flowability of all the formulations blend was significantly good. Prepared formulations showed average wetting time ranging from 40-45 seconds, average dispersion time with 3-6 minutes. In-vitro dissolution profile indicated the cumulative % drug release between 30-80% for most of the cases. Keywords: Orally disintegrating tablets, Tramadol hydrochloride, Superdisintegrants, Direct compression. *Address for Correspondence: Nusrat Ahmed, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh. ORCID ID: https://orcid.org/0000-0002-6059-0247 INTRODUCTION Many patients like pediatric and geriatric, disabled, bedridden or uncooperative, face difficulties while taking traditional dosage forms like tablets due to swallowing problem. Orally disintegrating tablets (ODTs) can be a better alternative for these kind of patients, as they are more convenient and patient compliant. Orally disintegrating tablet rapidly disintegrates and dissolves in saliva when placed upon tongue and does not require additional water for swallowing. 1, 2 United States Food and Drug Administration (FDA) defined ODT as “A solid dosage form containing medicinal substance or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue”. European Pharmacopeia used the term orodispersible tablets and defined as a tablet that when placed in the mouth disperses within 3 minutes before swallowing. 3, 4 The aim of this study was to formulate ODTs to achieve rapid disintegration in the mouth without water. Study was designed by using different superdisintegrates- croscarmellose sodium, sodium starch glycolate and crospovidone at different concentrations to evaluate their effect on various quality parameters. Tramadol hydrochloride was selected as the model drug in the study. Tramadol is a centrally acting, synthetic opioid analgesic, which is used to treat moderate to severe pain like postoperative pain, traumatic pain and cancer pain. It is rapidly absorbed after oral administration with mean bioavailability of approximately 75%. Its onset of action is occurred within 30-60 minutes and elimination half-life is about 6 hours. 1, 5, 6 The capsule dosage form and sustained release tablet of tramadol hydrochloride are available in Bangladesh for oral administration. There is no marketed ODT preparation in Bangladesh, but in USA and Europe tramadol hydrochloride ODT preparations are currently available. Thus, in this work an attempt has been taken to formulate and evaluate orally disintegrating tablets of tramadol hydrochloride. MATERIALS AND METHODS Materials: Tramadol hydrochloride API (Active Pharmaceutical Ingredient) was obtained from Beximco Pharmaceuticals Ltd. as a gift sample. Other excipients were obtained from Pharmaceutical Technology Lab, University of Dhaka. Nine