International Surgery Journal | December 2019 | Vol 6 | Issue 12 Page 4435 International Surgery Journal Gupta A et al. Int Surg J. 2019 Dec;6(12):4435-4439 http://www.ijsurgery.com pISSN 2349-3305 | eISSN 2349-2902 Original Research Article Prognostic role of serum C-reactive protein in carcinoma oesophagus Arun Gupta, Tejinder Singh Dall*, Darpan Bansal INTRODUCTION Oesophageal cancer (EC) is the eighth most common cancer around the world. 1 EC incidence and mortality are affected by geography. Eastern Asia, eastern and southern Africa have the highest rates, whereas Europe and North America show lower rates. In India at state level, extremely high incidence rates, reaching endemic proportions, have been reported from Jammu and Kashmir. In Punjab the incidence rates calculated were however lowest in the country. 2 In the US and Europe 85% of cases of oesophageal cancers are attributed to alcohol and tobacco use. 3 In India, etiopathogenesis of EC is attributed to multiple factors including malnutrition (vitamin A, E, C, riboflavin and niacin along with deficiency of micronutrients such as molybdenum and zinc) and betel quid chewing (relative risk 1.5 to 3.5). 4-8 Prognostication in cancer can be either subjective or objective. In the former, dependent on clinician skill and experience, it is often inaccurate and usually overly optimistic. 2 Despite advances in medical technology and biology, it is still an inexact science even with extensive ABSTRACT Background: Oesophageal cancer (EC) is the eighth most common cancer around the world. EC incidence and mortality are affected by geography. Eastern Asia, eastern and southern Africa has the highest rates, whereas Europe and North America show lower rates. Methods: The study was conducted on 30 cases of EC diagnosed in Sri Guru Ram Das Institute of Medical Sciences and Research, Sri Amritsar. The study was carried during period starting from January 2017 to June 2018. Serum C - reactive protein levels measurement was made in addition to the other routine investigations. Results: The sample consisted of 30 patients presenting with EC. Total number of males was 7 (23.33%) and there were 23 (76.66%) females. It was found in present study that the most common age group presenting with oesophageal cancer was 41-60 years followed by 61-80 years. It was also observed in the present study that majority of patients 15 (50%) were housewives. It was also observed that 17 (56.67%) of patients had more than 6 mg/l level of preoperative C-reactive proteins. Among the poorly differentiated histological grade patients 14 (73.68%) had high level of C-reactive proteins. Moreover hospital stay was also more among the patients having high pre-operative levels of C-reactive proteins (CRPs). Conclusions: The prognosis for patients with preoperative serum elevation of CRP was significantly more unfavourable than that for patients without serum CRP elevation. Keywords: Carcinoma oesophagus, C-reactive proteins, Dysphagia Department of Surgery, Sri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Sri Amritsar, Punjab, India Received: 05 November 2019 Revised: 21 November 2019 Accepted: 22 November 2019 *Correspondence: Dr. Tejinder Singh Dall, E-mail: drtejindersinghdall@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2349-2902.isj20195408