_____________________________________________________________________________________________________ *Corresponding author; Journal of Pharmaceutical Research International 33(62B): 290-294, 2021; Article no.JPRI.80737 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Osteopetrosis a Significant Bone Disease: A Case Study Sumit Vinod Gajbhiye a* , Suhas Tivaskar b , Anurag Luharia b and Ravi Christian a a School of Allied Health Sciences, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India. b Department of Radiology, School of Allied Health Sciences, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i62B35577 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/80737 Received 18 October 2021 Accepted 27 December 2021 Published 29 December 2021 ABSTRACT Background: Osteopetrosis is a genetic condition that affects just a few people. illness characterised by osteosclerosis, Due to inadequate osteoclast resorption, there is destruction of the medullary canal, calcified cartilage, and hard bone. Patients with osteopetrosis are more likely to develop osteoarthritis. Only a few studies have documented a patient who underwent both a complete Arthroplasty of the hip and knee (TKA). In this article, a patient with osteopetrosis describes a case of left and right hip osteoarthritis. Clinical Findings: Walking problems, Calcium deficiency, the optic nerve in the brain is under pressure. Hearing loss, as well as distress, can lead to neurological issues. Diagnostic Evaluation: CBC Investigation, blood test, Hb-12.9%, Total RBC count- 4.84million/cumm, RDW-13.2%, HCT-36.7%, Total WBC Count-26200 cu mm, Monocytes- 01%, Granulocytes- 30%, Lymphocytes- 65%, Total platelet count-3.5 Lacs/cu mm, ALT(SGPT)-17 U/L, AST (SGOT)-44 U/L. Peripheral Smear: RBCs-Normocytic Normochromic Platelets-Adequate on smear, No Hemiparasite seen, WBCs-Neutrophilic leucocytosis. Therapeutic Intervention: Calcium 1200mg, D3 8000IU, vitamin D supplements calcitriol 0.25mcg/ml, hormone replacement therapy, Bone marrow transplantation (BMT), Case Study