Jebmh.com Original Article J. Evid. Based Med. Healthc., pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 3/Issue 85/Oct. 24, 2016 Page 4647 COMPARATIVE ANALYSIS OF SILODOSIN AND TAMSULOSIN IN DISTAL URETERIC CALCULUS TREATMENT Govind Sharma 1 , Bharat Khadav 2 , T. C. Sadasukhi 3 , Manish Gupta 4 , H. L. Gupta 5 1 Assistant Professor, Department of Urology, Mahatma Gandhi Medical College and Hospital, Sitapura, Jaipur, Rajasthan. 2 Resident, Department of Urology, Mahatma Gandhi Medical College and Hospital, Sitapura, Jaipur, Rajasthan. 3 Professor, Department of Urology, Mahatma Gandhi Medical College and Hospital, Sitapura, Jaipur, Rajasthan. 4 Associate Professor, Department of Urology, Mahatma Gandhi Medical College and Hospital, Sitapura, Jaipur, Rajasthan. 5 Associate Professor, Department of Urology, Mahatma Gandhi Medical College and Hospital, Sitapura, Jaipur, Rajasthan. ABSTRACT BACKGROUND The urinary stone disease is one of the most common afflictions of the modern society and it has been described since antiquity with the westernisation of global culture. It has led to a lot of distress physically, mentally and financially to the affected individuals. Mini-invasive techniques like ESWL and ureteroscopy have their own negative aspects with discomfort to the patient being the prime in it. Hence, a need for conservative management in the form of pharmacotherapy has arisen in the past years and here we are investigating the same. The aim of the study is to compare the efficacy of silodosin (8 mg) vs. tamsulosin (0.4 mg) both in terms of the stone expulsion rate and the time to stone expulsion. MATERIALS AND METHODS A study comprising of 120 patients between the age group of 18-50 years with sonography-proven unilateral, uncomplicated lower ureteric calculus was undertaken from January 2015 to November 2015. Exclusion criteria were calculus more than or equal to 1 cm. Patients were divided in 2 Groups; Group A received silodosin 8 mg once daily for a month while Group B received tamsulosin 0.4 mg once daily. The patients were followed up weekly or biweekly with imaging studies. The endpoint was the stone expulsion rate and time, the rate of the interventions and the side effects. Settings and Design- With ethical committee clearance, a prospective study was conducted in the Department of Urology, Mahatma Gandhi Medical College and Hospital, Jaipur, India. Statistical Analysis- The SPSS-16 software was used for the statistical analysis of the data. RESULTS Results of our analysis showed that Group A (silodosin) patients were benefited more than Group B (tamsulosin) and it was also backed by the data showing a statistical significance for spontaneous stone expulsion in favour of the silodosin group. CONCLUSION Hence, we concluded that silodosin’s efficacy in treating patients with distal ureteric calculus was much better when compared to tamsulosin. KEYWORDS Efficacy, Expulsion Time, Expulsion Rate. HOW TO CITE THIS ARTICLE: Sharma G, Khadav B, Sadasukhi TC, et al. Comparative analysis of silodosin and tamsulosin in distal ureteric calculus treatment. J. Evid. Based Med. Healthc. 2016; 3(85), 4647-4649. DOI: 10.18410/jebmh/2016/979 BACKGROUND Urolithiasis is an ingrained disease of mankind, which has enormous public health importance and it accounts for a substantial economic burden on our society. Symptomatic ureteric calculi represent the most common condition encountered by an urologist in an emergency setting after urinary tract infections and pathologic conditions of the prostate. [1] Urolithiasis is the third most common disease of the urinary tract with an estimated prevalence of 2-3% and a lifetime recurrence rate of approximately 50%. [2] In the presence of normal renal function and absence of infection, observation is generally preferred for ureteric calculi measuring a maximum of 5 mm. [3] However, the spontaneous expulsion rate of distal ureter stone is about 25% if their size is between 4-6 mm, 5% if greater than 6 mm and calculi over 8 mm are very rarely eliminated spontaneously. [4] Therefore, active treatment is recommended for individual with larger stones, especially if their size is greater than 5 mm. Urolithiasis affects 12% of Financial or Other, Competing Interest: None. Submission 03-10-2016, Peer Review 09-10-2016, Acceptance 23-10-2016, Published 24-10-2016. Corresponding Author: Dr. Bharat Khadav, Department of Urology, Mahatma Gandhi Medical College and Hospital, Sitapura, Jaipur, Rajasthan. E-mail: bharatkhadav@gmail.com DOI: 10.18410/jebmh/2016/979