CLINICAL GUIDES IN ONCOLOGY Spanish Society of Radiation Oncology clinical guidelines for stereotactic body radiation therapy in lymph node oligometastases A. J. Conde-Moreno 1 • J. L. Lopez-Guerra 2 • V. A. Macias 3 • M. L. Va ´zquez de la Torre 4 • P. Samper Ots 5 • S. San Jose ´-Maderuelo 6 • J. Pastor Peidro 7 • J. Lo ´pez-Torrecilla 7 • J. Expo ´sito-Herna ´ndez 8 Received: 14 July 2015 / Accepted: 8 August 2015 Ó Federacio ´n de Sociedades Espan ˜olas de Oncologı ´a (FESEO) 2015 Abstract Data in the literature support the existence of a state of limited metastases or oligometastases. Favorable outcomes have been observed in selected patients with such oligometastases that are treated with local ablative therapies, which include surgical extirpation, stereotactic body radiation therapy (SBRT), and radiofrequency abla- tion. The role of SBRT in the setting of lymph node oligometastases is still emerging but the early results for local control are promising. However, the biggest chal- lenge is to identify patients who will benefit from treatment of their oligometastatic disease with local aggressive therapy. Patients are initially categorized based upon examination of the initial biopsy, location, stage, and previous treatments received. Appropriate patient man- agement with SBRT requires an understanding of several clinicopathological features that help to identify several subsets of patients with more responsive tumors and a good tolerance to SBRT. In an effort to incorporate the most recent evidence, here the Spanish Society of Radiation Oncology presents guidelines for using SBRT in lymph node oligometastases. Keywords Lymph node oligometastases Á SBRT Á SABR Á Adenopathies Á Radiosurgery & A. J. Conde-Moreno antoniojconde@gmail.com J. L. Lopez-Guerra chanodetriana@yahoo.es V. A. Macias victormaciash@gmail.com M. L. Va ´zquez de la Torre maria.luisa.vazquez.de.la.torre.gonzalez@sergas.es P. Samper Ots pilar.samper@hospitalreyjuancarlos.es S. San Jose ´-Maderuelo sol.sanjose@quiron.es J. Pastor Peidro jpastor@eresa.com J. Lo ´pez-Torrecilla jltorrecilla@eresa.com J. Expo ´sito-Herna ´ndez jose.exposito.sspa@juntadeandalucia.es 1 Radiation Oncology, Hospital Provincial de Castellon, Dr. Clara n 19 Ave, Castellon, Spain 2 Radiation Oncology, University Hospital Virgen del Rocio, Manuel Siurot Ave s/n, 41013 Seville, Spain 3 Radiation Oncology, Salamanca University Hospital, Paseo de San Vicente, Salamanca, Spain 4 Unidad de Oncologı ´a Radiotera ´pica, Hospital Meixoeiro- Galaria, Vigo, Hospital Meixoeiro, C/Meixoeiro sn, 36300 Pontevedra, Spain 5 Oncologı ´a Radioterapica, Hospital Universitario Rey Juan Carlos, C/ Gladiolo s/n, Mostoles, Spain 6 Radiation Oncology, Hospital Quiro ´n Barcelona and Hospital Universitari Quiro ´n Dexeus, Plaza de Alfonso Comı ´n, 5, Barcelona, Spain 7 Servicio Oncologı ´a Radiotera ´pica-ERESA, Hospital General Universitario de Valencia, Avenida Tres Cruces n82, 46014 Valencia, Spain 8 Radiation Oncology, Hospital Universitario Virgen de las Nieves, Av. de las Fuerzas Armadas, 2, Granada, Spain 123 Clin Transl Oncol DOI 10.1007/s12094-015-1383-y