                     !                  ! "  #$$ %!   & ’    ($   ( )*+   # ) ,  #  , "  # S1. Fragments selected by using the in silico docking approach: proprietary name, number, protomol and percentage of inhibition. S2. NMR evaluation of ARNO interacting fragments. S3. STD measurement of the dissociation constant with fragment 1. S4. 1 H assignments of fragments and compounds. S5. Electron densities of bound compounds 1 and 1h. S6. Fragment 1 analogues. S7. Cartoon representation of the superimposition of the 1h-ARNO Sec7 and ARF1-ARNO Sec7 (1R8Q) co-structures. S8. RMSD values of the apo structure at different pH and data collection and refinement statistics for the crystal structure (ph7.5) of the apo form of ARNO and of crystals soaked with 1h (pH 8.5) or 1 (pH 7.5 and 8.5). S9. Binding to ARNO Sec7 of fragments and compounds by SPR.