www.wjpps.com Vol 4, Issue 08, 2015. 21 Yasin et al. World Journal of Pharmacy and Pharmaceutical Sciences IMMUNOMODULATORS FROM PLANT SOURCE: A REVIEW Hina Yasin* 1 , Fakhsheena Anjum 1 , Hina Abrar 2 , Sana Ghayas 1 , Muhammad Ali Masood 1 , Tamha Fatima 1 , Mariam Naz 1 , Wajiha Jabeen 1 1 Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan. 2 Baqai Medical University, Karachi, Pakistan. ABSTRACT The use of phytochemicals has been a supportive practice for our immune system against infections since centuries as these drug substances enhance the immune response against infections. There are abundant plants which possess immunomodulatory and immunostimulatory activities. The immunomodulatory activities of various substances existing in natural sources have been determined in this article through literature review. Various techniques are also determined through which separation and isolation of such substances could be done in Pakistan. The present review will focus on latest developments regarding immunomodulatory activities of plants which have been reported from the year 2000 to early 2012. KEYWORDS: Immunomodulatory agent, phytochemicals, plant source, Tinospora cordifolia, Allium sativum, Curcuma longa. INTRODUCTION Immunomodulators can be broadly categorized as immunoadjuvants, immunostimulants and immunosuppresants. Immunoadjuvants are used to escalate the effectiveness of vaccines and since particular immunoadjuvants are used with particular vaccines, thus they could be considered as specific immunostimulants. Non availability of an appropriate adjuvant for human use has been one of the important tripping blocks in our skills to develop different vaccines like malarial vaccines. [1] Immunostimulants are integrally non-specific in nature as they are predicted to augment body's resistance against infection. They can act via distinctive immune and adaptive immune WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 5.210 Volume 4, Issue 08, 21-36. Review Article ISSN 2278 – 4357 Article Received on 25 May 2015, Revised on 16 June 2015, Accepted on 07 July 2015 *Correspondence for Author Dr. Hina Yasin Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.