Global Advanced Research Journal of Microbiology (ISSN: 2315-5116) Vol. 3(8) pp. 133-143, October, 2014 Available online http://garj.org/garjm/index.htm Copyright © 2014 Global Advanced Research Journals Full Length Research Paper Synthesis, spectroscopic, Thermal kinetic and computational studies on Charge-Transfer Complexes: (Panto & Ome)-prazole drug as donor and DDQ, CHLC & Iodine as acceptor Doa'a Fawzi Ba'amer 1 , Elsayed El-Mossalamy 2 , Laila Mohammad Al-Harbi 1* , Abdullah Yousif Obaid 1 1 Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 42805 Jeddah 21551 Saudi Arabia. 2 Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt. Accepted 10 October, 2014 Charge transfer (CT) complexes were carried out using the most widely selling and effective pharmaceutical drugs as Pantoprazole (PANT) and Omeprazole (OMER) as electron donors; solid interaction with different benzoquinone derivatives as acceptors and Iodine were isolated and characterized by IR and 1 H-NMR (Nuclear magnetic resonance) .Thermo gravimetric analysis with different heating rates (TGA) were studied on solid state complexes using computational integral methods for Coats Redfern and Ozawa using various solid state kinetic reaction models and established activation energy, energy band gape and thermodynamic parameters . The Differential Scanning Calorimetric (DSC) technique was used to study the nature decomposition of charge transfer complexes. The morphological structure were discussed and examined via Scanning Electron Microscopy (SEM).The molecular structures of Pentaprazole, DDQ, CHLC and I 2 & charge transfer complexes in the ground state were made by using Gaussian 03 program package. Keyword: thermal kinetic studies, pharmaceutical drugs, benzoquinone derivatives, Computational chemistry. INTRODUCTION Mulliken was the first who introduced the charge transfer phenomena (Mulliken 1952). The organic charge transfer complexes were intensively investigated due their application in many biological fields, solar energy storage, surface chemistry and their uses in quantitative estimation of drugs[2].In this study Omeprazole (OMER) {5-Methoxy- 2[[ 4- methoxy-3, 5-dimethyl-2-pyridinyl ]sulfinyl] - 1H- *Corresponding Author's Email: sbdmina@yahoo.com; Tel: +20-1009143680. benzimidazole} and Pantoprazle (PANT). {5-(Difluoronylmethoxy)-2-[[3,4-dimethoxy-2 pyridnyl)methyl]sulfinyl]-1H-benzimidazole}, in the form of {pantoprazole sodium sesquihydrate}, are two irreversible proton pump inhibitors (PPIs) are used as donors with benzoquinone derivatives as acceptors and Iodine. The formed charge transfer complexes are synthesized and characterized by mid infrared spectroscopy, elemental analysis, and proton magnetic resonance 1 HNM.Thermal studies were characterized by using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC).