American Journal of Medicine and Medical Sciences 2018, 8(3): 49-53 DOI: 10.5923/j.ajmms.20180803.03 The Relationship between Umbilical Obesity and Coronary Atherosclerosis Study in Monozygotic Goat Twins Evren Burşuk 1 , Omer Mehmet Erzengin 2 , Esra Erzengin Ozdemir 3 , Faruk Erzengin 4,* 1 Program of Biomedical Technologies, University of Istanbul, Vocational School of Technical Sciences, Istanbul, Turkey 2 Department of Gynecology, University of Istanbul, Veterinary Faculty, Istanbul, Turkey 3 Department of Business (Statistical), University of Beykent, Faculty of Economics and Administrative Sciences, Istanbul, Turkey 4 Department of Cardiology, Previous Dean, University of Istanbul, Istanbul Medical Faculty, Istanbul, Turkey Abstract We have recently proved that; there is a close relationship between umbilical obesity and coronary atherosclerocalcifications. We have investigated 36 monozygotic male goat twins relationship between umbilical obesity and coronary atherosclerosis. Randomly selected 12 goats were left to graze in open pasture (B), and the remaining 24 were kept in stables and pens (A), and fed the identical feed. The A group goats were observed having all umbilical obesity and also after slaughter process, more prominent epicardial fat tissue were seen macroscopically. The remaining unslaughtered 12 goats of Group A were treated for atherosclerosis for 6 months, using a combination of drug. All of the Group A goats had indicators of obesity in their body and visible epicardial fat tissue was observed, atherosclerocalcific plaques were found in the coronary artery, and some narrowing was observed in artery lumens. Making a comparison between Group A and Group B was found statistically significant (p=00001) our results. The remaining 12 goats were treated for atherosclerosis for 6 months, using a combination of drugs. Following the treatments, very little epicardial fat tissue was observed, and 8 of the goats had perfectly normal coronary arteries with the remaining four having minimal atherosclerosis plaques. The Group A goats had significant obesity unlike Group B as well as epicardial fat tissue and significant coronary atherosclerocalcifications. Moreover, the unslaughtered ones of Group A were treated with ideal drugs, epicardial fat tissue and coronary atherosclerosis declined significantly compared to their co-twins that did not receive this treatment. Keywords Umbilical obesity, Coronary atherosclerosis, Pericardial fat 1. Introduction Despite the steady progress in the treatment of atherosclerotic and atherothrombotic cardiovascular diseases, coronary artery diseases and myocardial infarctions continue to be significant causes of morbidity and mortality, especially in industrialized countries. The term atherosclerosis refers to the thickened and hardened lesions, which have lipids and at the end calcifications in the intimae and media of elastic and muscular arteries. To date, the primary cause of arterial atherosclerotic calcifications has not yet been elucidated. It is generally accepted that atherosclerotic and calcified lesions first appear and develop within the innermost layer of the arteries (at the intimae) (Figure 1). * Corresponding author: farukerzengin@gmail.com (Faruk Erzengin) Published online at http://journal.sapub.org/ajmms Copyright © 2018 Scientific & Academic Publishing. All Rights Reserved Lumen Epithelium Lipids Intimae Media Adventitia Figure 1. Classical pathway and accumulation of the lipids core in the intimae have been shown in this figure Formation and progression of atherosclerotic plaques and calcifications in all arterial beds of intimae have been well documented by AHA (American Heart Association) and many authors, such as V. Fuster and E. Falk [1-4], who subdivided the formation and progression of these plaques into several phases. As known, atherosclerosis plays a major role in development of arterial calcification. Non-conjugated matrix GLA and osteonegrin proteins are also effective in the formation of this calcification [5-7]. Most lipids deposited in atherosclerotic lesions