1 Scott et al., 2015 Revision #3 KATP CHANNEL DEFICIENCY IN MOUSE FDB CAUSES AN 1 IMPAIRMENT OF ENERGY METABOLISM DURING FATIGUE 2 by 3 Kyle Scott 1A , Maria Benkhalti Jandu 1A , Nicholas D. Calvert 1 , Mathieu Paquette 1 , Li Zhen 1 , 4 Mary-Ellen Harper 2 , Osama Y. Al-Dirbashi 3 and Jean-Marc Renaud 1 5 1 Department of Cellular and Molecular Medicine and 2 Department of Biochemistry, 6 Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd., 7 Ottawa Ontario, Canada, K1H 8M5; 3 Newborn Screening Ontario, Children's Hospital of 8 Eastern Ontario, 401 Smyth Rd., Ottawa, Ontario Canada, K1H 8L1 9 Footnote: A K. Scott and M. Jandu have equal contribution to this paper 10 Running title: KATP channel deficiency and muscle energy metabolism 11 Keywords: glucose, glycogen, lactate, CO2 12 13 CORRESPONDENCE: Dr. Jean-Marc Renaud 14 University of Ottawa 15 Department of Cellular and Molecular Medicine 16 451 Smyth Rd. 17 Ottawa Ontario 18 Canada 19 K1H 8M5 20 Tel.: (613) 562-5800 x8156 21 Fax: (613) 562-5434 22 E-mail: jmrenaud@uottawa.ca 23 Articles in PresS. Am J Physiol Cell Physiol (August 3, 2016). doi:10.1152/ajpcell.00137.2015 Copyright © 2016 by the American Physiological Society.