Int. J. Bioinformatics Research and Applications, Vol. 16, No. 1, 2020 59 Copyright © 2020 Inderscience Enterprises Ltd. A comparison of genetic imputation methods using Long Life Family Study genotypes and sequence data with the 1000 Genome reference panel Aldi T. Kraja*, E. Warwick Daw, Petra Lenzini, Lihua Wang, Shiow J. Lin and Christine A. Williams Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Farrell Learning Center, S. Euclid Ave., St. Louis, MO 63110, USA Email: aldi@wustl.edu Email: warwick@wustl.edu Email: plenzini@wustl.edu Email: lwang@wustl.edu Email: rosa@wustl.edu Email: cwilliams@wustl.edu *Corresponding author Alan B. Wells Clinical and Translational Research Institute, University of California San Diego, San Diego, CA 92093, USA Email: abwells@ucsd.edu Kathryn L. Lunetta Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA Email: klunetta@bu.edu Joanne M. Murabito Section of General Internal Medicine, Boston University School of Medicine and Framingham Heart Study, Boston, MA 02218, USA Email: Murabito@bu.edu