Indian Journal of Clinical and Experimental Ophthalmology 2021;7(2):448–451 Content available at: https://www.ipinnovative.com/open-access-journals Indian Journal of Clinical and Experimental Ophthalmology Journal homepage: www.ijceo.org Case Report Juvenile open angle glaucoma –A case series study Shams Mohammed Noman 1, * 1 Dept. of Ophthalmology, Bangabondhu Shekh Mujib Medical University, Dhaka, Bangladesh ARTICLE INFO Article history: Received 21-04-2021 Accepted 21-04-2021 Available online 30-06-2021 Keywords: Juvenile open angle glaucoma Trabeculectomy ABSTRACT Background: Juvenile open angle glaucoma is a rare form of glaucoma that differs from primary open angle glaucoma in its age of onset and magnitude of intraocular pressure. Juvenile open angle glaucoma has its onset between 3-40 years of age with relatively high intraocular pressure. Purpose: For the documentation and describe clinical manifestations management and outcome of management of the patients diagnosed as Juvenile open-angle glaucoma at the glaucoma department, CEITC, Chittagong, Bangladesh. Materials and Methods: This is a hospital based prospective observational case series review. 20 patients who were diagnosed as Juvenile open-angle glaucoma from November 2010 to December 2011 were included in this study. Patient particulars history with main causes of hospital presentations were recorded. Ophthalmic examinations and management given were documented. Similar relevant details were recorded for different follow-up periods. Results: 40 eyes of 20 patients were included in this study. There were 16 male and 4 female. All cases were bilateral. Age more than 18yrs. (18-35) in 16 patients and below 18yrs. (5-18) in 4 patients. 15 patients came from rural area and 5 patients from urban. Pretreatment average IOP in the both eyes was 32±3mmhg, which was 15±1mmhg after treatment. 24 of 40 eyes were presented with advance field defects. 85% (17 patients) had myopic refractive error. In 18eyes pre treatment presenting visual acuity was <6/60 and >6/60 in the rest of the eyes. Visual acuity was improved after treatment. In 21 patients (53%) IOP was controlled with 2-3 medications. In 19 eyes (48%) IOP was controlled with filtration surgery. Conclusion: As Juvenile open-angle glaucoma presented with high IOP and advance field defect, early diagnosis, appropriate investigations and medical or surgical management is mandatory to stabilize IOP and to prevent progression of field defects. © This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 1. Introduction Juvenile open-angle glaucoma (JOAG) which has an age at onset of (5-35) years tends to be more aggressive. It is usually resistant to medical therapy and is associated with more severe visual impairment than primary open angle glaucoma. 1 The estimated prevalence of JOAG ranges from 0.38to 2 in 100000 in individuals between 4-20 years of age and 4 * Corresponding author. E-mail address: drshams_noman@yahoo.com (S. M. Noman). percent of child hood glaucoma. Identifying risk factor are important because this information may lead to development of strategies for disease screening and prevention and may be useful in identifying persons for whom close medical supervision is indicated. Thick compact tissue in the angle represents an immature development of the trabecular meshwork and may be one of the primary cause of increase intraocular pressure in Juvenile glaucoma 2 the more extensive the immaturity, the earlier the glaucoma will become manifest. GLCIA, the first open angle glaucoma gene, was initially https://doi.org/10.18231/j.ijceo.2021.089 2395-1443/© 2021 Innovative Publication, All rights reserved. 448