Rachana K.L. et al / Int. J. Res. Ayurveda Pharm. 11 (6), 2020 37 Research Article www.ijrap.net (ISSN:2229–3566) AN EXPERIMENTAL STUDY TO EVALUATE CARDIOPROTECTIVE ACTIVITY OF JINGINI LANNEA COROMANDELICA MERR (HOUTT): AN IN VIVO STUDY Rachana K. L. * 1 , Giri Prashanth K.G 2 , Manjunatha P. Mudagal 3 , Seema Pradeep 4 , Yashaswini B.K 1 , Varuni B.G. 1 1 PG Scholar, Department of PG studies in Dravya guna Karma Vijnana, Sri Sri College of Ayurvedic Science and Research Hospital, Bangalore, Karnataka, India 2 Professor and Guide, Department of PG Studies in Dravya guna Karma Vijnana, Sri Sri College of Ayurvedic Science and Research Hospital, Bangalore, Karnataka, India 3 HOD and Co-guide, Department of Pharmacology, Acharya and BM Reddy College of Pharmacy, Hesaraghatta, Bangalore, Karnataka, India 4 HOD, Department of PG Studies in Dravya guna Karma Vijnana, Sri Sri College of Ayurvedic Science and Research Hospital, Bangalore, Karnataka, India Received on: 06/10/20 Accepted on: 16/11/20 *Corresponding author E-mail: dr.klr.lucky@gmail.com DOI: 10.7897/2277-4343.1106182 ABSTRACT Jingini - Lannea coromandelica Merr. (Houtt) is mentioned in Bhava Prakasha Nighantu and Bhavamishra advocates JINGINI for Hridroga. An experimental study was designed with a Model - Isoproterenol (ISO) Induced Cardiac toxicity in order to prove the efficacy of JINGINI for its Cardioprotective activity. Animals were administered with Aqueous and Methanolic extract of JINIGINI in higher and lower dose. The Acute toxicity studies were conducted up to 5000 mg/kg body weight in accordance with OECD 425 guidelines. The higher dose calculated from 1/5 th of 5000 mg/kg body weight which summed up to 1000 mg/kg body weight and lower dose calculated from 1/10 th of 5000 mg/kg body weight was concluded as 500 mg/kg body weight. The Methanolic extract of JINGINI in Higher and Lower dose (1000 mg/kg body weight and 500 mg /kg body weight respectively) was found to be efficacious in providing the Cardio-protective action in SD Rats. Keywords: Jingini, Cardioprotective activity, Isoproterenol (ISO) INTRODUCTION Classical Ayurveda elaborates on Hridaya (Heart) and the pathologies related to it systematically with the dedication of various chapters in Bruhatrayi and Laghutrayi. The other medieval period treatises describe Hridroga with its treatment aspects. Bhavamishra has indicated JINGINI in Hridroga in Vatadi varga of Bhava Prakasha Nighantu. 1 Hridaya is an organ which draws blood from different parts of the body and in turn supplies it to different parts of the body (ha- harati/to receive from, da-dadaati/to give, ya-yagati/to control). It is one of the important Marma and Pranayatanas. It is the Moola Sthaanafor Rasa and Raktavaha srotas. Embryologically, Hridaya originates from the Sara Bhaga of Rakta Dhatu and Kapha Dosha. The shape of the heart is mentioned as Inverted Lotus. Most importantly Hridaya is the Sthaana for Udaaba Vata, Vyaana Vata, Praana Vata, Sadhaka Pitta, Avalambaka Kapha and Ojas. It is also elucidated that Hridaya is Sthaana for Praana, Buddhi, Manas. 2 The concept of Hridya is well described in Classics. Acharya Charaka ornated Hridaya Mahakashaya varga elaborating it as Cardiac tonic drugs which are meant to improvise and strengthen the Heart through its structure and function and catalyzes the maintenance of Cardiac health. We not only find references of Hridroga in separate dedicated chapters but also, we find Hridroga mentioned as Lakshana in certain diseases. In Vataja Kasa; Hrut shoola is one of the Lakshana. In Kshayaja kasa “Hrudayam Manyatecchyutam” meaning the rogi of Kshayaja Kasa feels as though his heart is falling down and will be displaced from its actual position. Most importantly the Classical formulations mentioned for different types of Kasa out of which few are also indicated for Hridroga (e.g. Pippalyadi ghrita etc.). 3 Ischemic heart disease and stroke are the predominant causes and are responsible for > 80% of CVD deaths. The Global Burden of Disease study estimate of age-standardized CVD death rate of 272 per 100 000 population in India is higher than the global average of 235 per 100000 population. 4 Cardio- protection includes all the mechanism and means that contribute to the preservation of heart by reducing or even preventing Myocardial damage. Cardiovascular disease (CVD) remains the principal cause of death in both developed and developing countries. CVD includes High blood pressure, Coronary heart disease, Congestive heart failure, Stroke and account to Myocardial Infarction which causes interruption of blood supply to apart of the heart leading heart cells to die, commonly due to blockage of coronary artery. Cardio-vascular deaths remain the leading cause of death in India. Therefore, finding ways to reduce the mortality of Cardio- vascular disease remains an important health goal. Herbal drugs are known to exhibit creditable medicinal properties for the treatment of heart ailments and need to be explored for its potential application in prevention and therapy of human ailments. More than 2000 plants have been listed in the Traditional (Herbal/Alternative) systems of medicine and some of these are providing comprehensive relief to the people