~ 917 ~ Journal of Entomology and Zoology Studies 2019; 7(4): 917-921 E-ISSN: 2320-7078 P-ISSN: 2349-6800 JEZS 2019; 7(4): 917-921 © 2019 JEZS Received: 08-05-2019 Accepted: 10-06-2019 Binita Baruah M.V.Sc. Scholar, Department of Pathology, C.V.Sc. AAU Khanapara, Guwahati, Assam, India Sarojini Mahanta Tamuli Professor, Department of Pathology, C.V.Sc. AAU. Khanapara, Guwahati, Assam, India Shantanu Tamuly Assistant Professor, Department of Biochemistry, C.V.Sc. AAU. Khanapara, Guwahati, Assam, India Correspondence Binita Baruah M.V.Sc. Scholar, Department of Pathology, C.V.Sc. AAU Khanapara, Guwahati, Assam, India Prevalence and Haemato-biochemical studies on Hepato-renal dysfunction in pigs Binita Baruah, Sarojini Mahanta Tamuli and Shantanu Tamuly Abstract The present study was conducted with an objective to study the prevalence of hepato-renal dysfunction in pigs. Blood samples were collected from a total of 90 clinically affected pigs in and around Guwahati, Assam. In this study, a total of 53 (58.8%) cases were recorded as positive out of which 25 (27.7%) for hepatic, 17 (18.8%) for hepato-renal and 11(12.2%) for renal dysfunctions respectively. Haemato- biochemical values of different parameters generated from the study were analyzed statistically. Haematological parameters viz. haemoglobin (g/dl). Packed cell volume (%), total erythrocyte count (10 6 /mm 3 ), total leukocyte count (10 3 /mm 3 ), differential leukocyte count (%), thromobocyte count (10 3 /mm 3 ), Mean corpuscular haemoglobin (MCV), Mean corpuscular haemoglobin (MCH) and Mean corpuscular haemoglobin concentration (MCHC) revealed that pigs suffered from hypochromic microcytic anaemia,. Biochemical marker included in liver and kidney function tests revealed that affected pigs showed moderate to severe dysfunction of liver and kidneys. Keywords: Biochemical, haematological, hepato-renal, dysfunction, pig Introduction In India, pig husbandry is playing a significant role in rural livelihood programme, particularly among the tribal belt in the country. Pig husbandry contributes to economic growth through the generation of employment and foreign exchange. India possesses 11,133 pigs which contribute 2% of the world’s pig population (19 th livestock census). Eastern and North Eastern (NE) states of India possesses highest pig population. The pig population in Assam is 1.63 million which share 15.89% of total India’s pig population. Liver and kidneys are two most important vital organs, that perform varieties of metabolic functions within the body. Liver and kidneys are most common vital organs subjected to various injuries and insults. Hepatic failure is a syndrome that results from inadequate hepatic function, may be the result of sudden massive hepatic destruction or more frequently the end point of progressive liver damage. Usually, liver failure is accompanied by the signs of kidney dysfunction such as anuria, oliguria and biochemical alterations. Pathogenesis of hepato-renal dysfunction is related to alteration of arterial blood volume due to reduce venous return and cardiac output (Jubb et al., 2007 and Jones et al., 2006). Increased compensatory vasoconstriction of renal circulation causes decrease rate of glomerular filtration and resultant renal failure. Kidneys might show minimal pathologic changes but prognosis is grave (Tari, 2016) [20] . Materials and Method Blood samples were collected from clinically affected pigs from organized and unorganized farms located in and around Guwahati, Assam. The whole blood collected from clinically affected pigs were subjected to study different haematological parameters viz., haemoglobin (g/dl), Packed cell volume (%), total erythrocyte count (10 6 /mm 3 ), total leukocyte count (10 3 /mm 3 ), differential leukocyte count (%), thrombocyte count (10 3 /mm 3 ), Mean corpuscular haemoglobin (MCV), Mean corpuscular haemoglobin (MCH) and Mean corpuscular haemoglobin concentration (MCHC) with the help of automated haematology cell counter model MS4e (Melet Schloesing Labaoratories -9 Chaussee Jules Cesar-Porte 402-95520 OSNY, France). Biochemical analysis was done by using kits for estimation of GD (Glutamate dehydrogenase), ALT (Alanine aminotransferase), AST (Aspartate aminotransferase), Total protein, Glucose, Total bilirubin, Direct bilirubin, BUN (Blood urea nitrogen) & creatinine as per standard methods. Data obtained in the present experiment were analyzed statistically by Graph pad prism 7.0 [Analysis of variance (ANOVA, F test].