_____________________________________________________________________________________________________ *Corresponding author: E-mail: ffaruki@bhmcny.org; International Journal of Medical and Pharmaceutical Case Reports 14(3): 25-28, 2021; Article no.IJMPCR.74721 ISSN: 2394-109X, NLM ID: 101648033 Case Report: Risperidone Induced Peripheral Edema Farzana Faruki 1* , Uma Datta Gupta 2 , Adeel Anwar 1 and Saral Desai 1 1 One Brooklyn Health System, United States of America. 2 Chittagong Medical College, Bangladesh. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IJMPCR/2021/v14i330136 Editor(s): (1) Dr. Erich Cosmi, University of Padua School of Medicine, Italy. Reviewers: (1) Priyal Shrivastava, Jawaharlal Nehru Medical College, India. (2) Marcel Vasconcellos, Centro Universitário Serra dos Órgãos (UNIFESO), Brazil. Complete Peer review History: https://www.sdiarticle4.com/review-history/74721 Received 13 July 2021 Accepted 23 September 2021 Published 28 September 2021 ABSTRACT Risperidone is the first line of treatment for bipolar disorder, atypical depression, and Schizophrenia. We present a 55-year-old male with a history of schizoaffective disorder with bipolar type I presented with aggressive behavior and suicidal ideation. Our patient was treated with low- dose Risperidone; after that, he gradually developed leg pain and edema. His leg pain hampers his ambulation, which is clinically improved after a week of medication discontinuation; however, his leg edema did not resolve completely. In addition, we evaluated our patient's compliance with an empathic verbal interview that shows edema and leg pain hampers his quality of life. We have found that not informing edema as one of the possible side effects increases medication non- compliance in our case. There are several case reports about the side effect of Risperidone (such as leg edema) in combination with other medications, but there is no recommendation about patient counseling of forthcoming leg edema and mobility issues. Keywords: Bipolar disorder; schizoaffective disorder; mental disorder; risperidone. Case Study