International Journal of Molecular Biology & Biochemistry. ISSN 2349-2341 Volume 4, Number 1 (2016), pp. 27-42 © International Research Publication House http://www.irphouse.com Plants as Latent Sources of New Antimicrobials and Resistance Modifying Agents Against Multi Drug Resistant (MDR) Strains Vaidehi Patel 1 *, Dr. Rajesh Patel 2 1 Department of Microbiology, Shree K. K. Patel girls science college. 2 Department of life science, H.N.G.U, PATAN Abstract Antibiotic resistance has limited the use of cheap and old antibiotics, has necessitated to used higher class antibiotics. The need of higher class antibiotics need a continued search for new antimicrobial compounds. Understanding the mechanisms of resistance is important in the development of strategies to solving the problem. Active efflux of drugs, alteration of target sites and enzymatic degradations are the strategies by which pathogenic bacteria acquire or develop intrinsic resistance to antibiotics. Multi-drug resistance (MDR) pumps, capable of recognizing and expelling a variety of structurally unrelated compounds from the bacterial cell and conferring resistance to a wide range of antibiotics have since been characterized in many Gram positive and Gram negative pathogens like Staphylococcus au reus, Pseudomonas ae ruginosa, Escherichia coli and, more recently, in mycobacteria. The ability of some chemical compounds (called MDR inhibitors or resistance modifying agents) to modify the resistance phenotype in bacteria by working synergistically with antibiotics in vitro has since been observed. The search for such compounds which can be combined with antibiotics in the treatment of drug resistant infections may be an alternative to overcoming the problem of resistance in bacteria. Crude extracts of medicinal plants stand out as veritable sources of potential resistance modifying agents. Keywords: MDR, plant extract, resistant modifying agent 1. Introduction Infectious diseases caused by bacteria and fungi affect millions of people worldwide. Throughout the history of mankind, infectious diseases have remained a major cause of death and disability. Today, infectious diseases account for one-third of all deaths