Characterizing COVID-19 Clinical Phenotypes and Associated Comorbidities and Complication Profiles Elizabeth R. Lusczek, PhD; 1* Nicholas E. Ingraham, MD;2* Basil S. Karam, MD3; Jennifer Proper, BA;4 Lianne Siegel, BA;4 Erika S. Helgeson, PhD;4 Sahar Lotfi-Emran, MD PhD;2 Emily J. Zolfaghari, MS;5 Emma Jones, MD;1 Michael G. Usher, MD;6 Jeffrey G. Chipman, MD;1 R. Adams Dudley, MD;2,7 Bradley Benson, MD;6 Genevieve B. Melton, MD PhD;1,7 Anthony Charles, MD MPH;8,9 Monica I. Lupei, MD;10 Christopher J. Tignanelli, MD.1,7,11 *Both authors contributed equally to this manuscript Author Affiliations: 1 Department of Surgery, University of Minnesota, Minneapolis, MN 2 Department of Medicine, University of Minnesota, Division of Pulmonary and Critical Care, Minneapolis, MN 3 Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 4 Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 5 University of Minnesota Medical School, Minneapolis, MN 6 Department of Medicine, University of Minnesota, Division of General Internal Medicine, Minneapolis, MN 7 Institute for Health Informatics, University of Minnesota, Minneapolis, MN 8 Department of Surgery, University of North Carolina, Chapel Hill, NC 9 School of Public Health, University of North Carolina, Chapel Hill, NC 10 Department of Anesthesiology, University of Minnesota, Minneapolis, MN 11 Department of Surgery, North Memorial Health Hospital, Robbinsdale, MN Correspondence: Nicholas Ingraham, MD MMC 276 420 Delaware St SE Minneapolis, MN 55455 Office: (612) 626-1968 Fax: (612) 626-0439 Email: ingra107@umn.edu NEI ingra107@umn.edu TS schac008@umn.edu JGC chipm001@umn.edu BB benso040@umn.edu CTJ ctignane@umn.edu MIL lupei001@umn.edu GMM gmelton@umn.edu DW wack0012@umn.edu RR rreilkof@umn.edu SE saharle@umn.edu BT thie0149@umn.edu ERL lusc0006@umn.edu JP prope012@umn.edu AC anthchar@med.unc.edu LS siege245@umn.edu MHS syed0021@umn.edu JR rhei0005@umn.edu MGU mgusher@umn.edu SI ikram001@umn.edu MA abass004@umn.edu Conflicts of Interest and Funding Source(s): 1. NIH NHLBI T32HL07741 (NEI) 2. This research was supported by the Agency for Healthcare Research and Quality (AHRQ) and Patient-Centered Outcomes Research Institute (PCORI), grant K12HS026379 (CJT) and the National Institutes of Healthｶs National Center for AdYancing Translational Sciences, grant KL2TR002492 and UL1TR002494. 3. NIH NHLBI T32HL129956 (JP, LS) Reprints will not be available from the authors. All authors significantly contributed to developing, writing, and revising this manuscript. All rights reserved. No reuse allowed without permission. preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this this version posted September 14, 2020. ; https://doi.org/10.1101/2020.09.12.20193391 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.