J Med Assoc Thai Vol. 93 Suppl. 2 2010 S87 Prevalence of Cirrhosis Registered in Nakhon Nayok, Thailand Suthee Rattanamongkolgul MD, MPH, PhD*, Chatchawan Wongjitrat MD**, Pichet Puapankitcharoen MD*** *Department of Preventive and Social Medicine, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Thailand **Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand ***Division of Internal Medicine, Nakhon Nayok General Hospital, Ministry of Public Health, Bangkok, Thailand Objective: To determine population-based prevalence rates of cirrhosis in Nakhon Nayok Province and patterns of the prevalence by sex, age groups and disease type. Material and Method: A retrospective descriptive study of medical record database was performed in all hospitals in the province of Nakhon Nayok during the year 2007. ICD-10 was used to identify patients with cirrhosis. Patient information was collected, including name, sex, address and age and data of population of Nakhon Nayok Province stratified by 5 year-age groups, sex and district of the province were obtained. Crude and standardised prevalence rates were calculated using WHO (2000) standard population. Results: There were 199 cirrhosis patients comprising 111 males (55.8%) and 88 females (44.2%) with average age of 54.7 years (SD, 13.0). Crude prevalence rate per 100,000 was 86.3 (95% CI: 74.3-98.3) and age standardized prevalence rate was 75.3 (95% CI: 64.8-85.8). Prevalence of alcoholic cirrhosis was 53.6 (95% CI: 44.8-62.5) and 21.7 (95% CI: 16.0-27.4) for non-alcoholic cirrhosis. Alcoholic cirrhosis in male was found in younger age groups than older age. The prevalence rates vary among four districts. Discussion: In this rural area in the central part of Thailand, the standardized prevalence rates is 75.3 per 100,000 and the prevalence is more common in male than female especially for alcoholic cirrhosis. Preva- lence of cirrhosis starts to rise from age of 30 to 60 years. Age distributions of non alcoholic cirrhosis in males and females are similar but in alcoholic cirrhosis the magnitude of prevalence in male is higher than female. Alcoholic cirrhosis is 2.6 folds more prevalent than non-alcoholic cirrhosis. Keywords: Cirrhosis, Nakhon Nayok, Prevalence, Age standardized rates, Alcoholic cirrhosis, Non-alcoholic cirrhosis, Sex difference J Med Assoc Thai 2010; 93 (Suppl. 2): S87-91 Full text. e-Journal: http://www.mat.or.th/journal Correspondence to: Rattanamongkolgul S, Department of Pre- ventive and Social Medicine, Faculty of Medicine, Srinakharin- wirot University, Maha Chakri Sirindhorn Medical Center, Ongkharak, Nakhon Nayok 26120, Thailand. Phone: 037- 395-085 ext. 10727. E-mail: suthee@swu.ac.th Globally, cirrhosis is one of the leading causes of deaths with annual mortality of 786,000. Worldwide mortality rate was 12.6 per 100,000 accounting for 1.4% of all causes of deaths in 2002 (1) . The estimated deaths of cirrhosis in Thailand were 9,131 deaths each year with the crude rates of 8.9 per 100,000 population (1) . Cirrhosis is one of the ten leading causes of burdens of diseases in males aged 30-59 in Thailand in 1999 (2) . The mortality rate in Thailand was shown to be increased while downward trends of mortality were observed in Hong Kong and Singapore (3) . Hepatitis B and C and alcohol consumption have been indicated as the main risk factors and probably contributing to the trend of the disease. Magnitudes of population with cirrhosis are useful for health authority for resource planning. Population data of the prevalence of the disease have not been studied in Thailand. This study therefore aims to quantify population-based prevalence of cirrhosis in Nakhon Nayok Province which is located in the cen- tral part of Thailand and also to examine distributions of the prevalence by sex, age groups, geography and type of the disease.