S1 Supporting information 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice Lars Johansson,* ,‡ Christopher Fotsch, § Michael D. Bartberger, § Victor M. Castro, ‡ Michelle Chen, § Maurice Emery, § Sonja Gustafsson, ‡ Clarence Hale, § Dean Hickman, § Evert Homan, ‡ Steven R. Jordan, § Renee Komorowski, § Aiwen Li, § Kenneth McRae, § George Moniz, § Guy Matsumoto, § Carlos Orihuela, § Gunnar Palm, ‡ Murielle Veniant, § Minghan Wang, § Meredith Williams, ‡,|| and Jiandong Zhang § Table of Contents Elemental Analysis Data S2 1 H NMR Spectra for Compounds 5b, 6b, 5i, and 6i S3 HPLC Systems S5 HPLC and HRMS Data S6 HPLC Chromatograms S7 X-ray Crystallographic Data for Human 11-HSD1 with 14 S28 X-ray Crystallographic Data for Human 11-HSD1 with (S)-6d S279 * To whom correspondence should be addressed. Phone +46-(0)8-6973804. Fax: +46-(0)8-6972320. E- mail: lars.johansson@biovitrum.com ‡ Biovitrum AB § Amgen, Inc. || Current address: S*Bio Pte Ltd, 1 Science Park Road, #05–09 The Capricorn, Singapore Science Park II, Singapore 117528