Introduction Film coating is a most significant unit operation in the pharmaceutical industry (Shukla et al., 2017). Film coatings are used for various purposes like improvement of visual qualities of dosage forms, masking disagreeable taste or odor, improving stability and modifying the release characteristics of the drug (Ali et al., 2008). Film coating is applied to a variety of pharmaceutical products like tablets, beads, pellets, granules, capsules and drug crystal (Beraa et al., 2016). Film layer can be formed from both polymeric solution (organic solvent or aqueous based) or aqueous polymeric dispersion (commonly called latex). Polymer is the main ingredient in film coating and it may be from different origins (natural, synthetic or semisynthetic), including cellulosic, acrylics, vinyl and combination of polymers (Brummer et al., 2003). Natural polymers are cheap, easily available, non irritant, biodegradable, biocompatible and eco-friendly. Fenugreek natural gum, it is extracted from the seed of Trigonellafoenum graecum (Family Leguminosae). It is cultivated in northern Africa, Canada, western Asia and India. Traditionally fenugreek seed are used in the treatment of diabetes (Dutta et al., 2005, Garg et al., 2018). Application of fenugreek seed gum have been reported as oral drug release retardant (Gowthamrajan et al., 2002, Ikoni et al., 2014, Kwok et al., 2004), binder (Nitalikar et al., 2013; Nayak et al., 2013; Nitalikar et al., 2013), mucoadhesive (Nokhodchi et al., 2008; Olga et al., 2016), emulsifiers (Rhodes et al., 1998; Rhodes et al., 2016; Rhodes et al., 2017), suspending agent (Senthil et al., 2011), gelling agent and formulation of nanoparticles (Sav et al., 2013; Shanmuganathan et al., 2016). Tamarind seed gum (TSG) has wide application in the drug delivery (Shukla et al., 2011). It has been reported that gum, TSG can be successfully extracted from tamarind seed, using water-solvent extraction method. It can be used in the formulation of sustained release drug dosage form of water- soluble and water-insoluble drugs (Shukla et al., 2018; Rhodes et al., 1998; Rowe et al.,1978 . The sustained release ) Isolation and characterization of natural and modified seed gum Ajay Kumar Shukla*, Ram Singh Bishnoi, Manish Kumar, C.P. Jain Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India * Corresponding Author: Address for Mr. Ajay Kumar Shukla, Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India E-mail: ashukla1007@gmail.com Abstract Objective: The objective of the present work was to investigate the film coating potential of Fenugreek seed gum (FSG), Tamarind seed gum (TSG), using paracetamol as a model drug. Fenugreek seed gum Materials and Methods: (FSG), tamarind seed gum (TSG), paracetamol tablets, hydroxypropylmethylcellulose (HPMC) and sodium alginate (SA). Core tablets of paracetamol were obtained from a pharmacy shop in the local market and were evaluated for weight, diameters, thickness, hardness, friability, and disintegration time. The core tablets were coated using 2% w/v solution of TSG, MTSG, FSG, MFSG and the release rate of drug from these coated tablets was compared to in-vitro the release rate of drug from the tablets coated with 2% w/v of HPMC. The tablets coated with natural and Results: modified tamarind seed gum, separately. The coated tablets are release the drug up to 10 hrs and 11 hrs, respectively and natural and modified fenugreek seed gum release the drug up to 7 hrs and 9 hrs respectively. The tablets coated with HPMC released the drug up to 14 hrs. The drug release profile of tablets coated with modified tamarind seed gum was comparable to the release profile of tablets coated with HPMC. On the basis of the drug release profile, it Conclusion: is concluded that FSG and TSG can be used as release rate controlling membrane of natural origin. Keywords: Fenugreek seed gum, pharmaceutical excipient, natural polymer Received: 12 September 2018 Revised: 10 October 2018 Accepted: 15 November 2018 Research Article www.ajpp.in DOI: https://doi.org/10.31024/ajpp.2019.5.2.27 2455-2674/Copyright © 2019, N.S. Memorial Scientific Research and Education Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Asian Journal of Pharmacy and Pharmacology 2019; 5(2): 409-418 409