2446 Indian Journal of Forensic Medicine & Toxicology, July-September 2021, Vol. 15, No. 3 Study of Some Physiological and Histological Parameters of Albino Rats Administrated with a Herbal Obesity Slimmer Product Ikhlass A. Al-Hilaly 1 , Meison Abdulbary 2 , Sadeq Jaffer AlZubaidi 3 , Ibraheem Mohammed 3 1 Assist. Prof., Department of Laboratory Investigations, Faculty of Sciences, University of Kufa, Republic of Iraq, 2 Prof., Department of Pharmacognosy and Medicinal Plant, Faculty of Pharmacy, University of Kufa, Republic of Iraq, 3 B.Sc., Department of Laboratory Investigations, Faculty of Sciences, University of Kufa, Republic of Iraq Abstract The modern studies on the treatment of obesity have dedicated on the potential activity of plants to control obesity on the metabolism of lipid and glucose. The aim of this study is to investigate about the effect of AB slim on body metabolism of its – takers and determine its safety. 16 female rats (150 - 250) divided equally into 4 groups, the frst group considered as control group and administered distilled water, the three other groups daily administered the prepared aqueous solution of AB slim capsule for 45 days. The animals weighed after 24 hr. of the last administration, the animals were weighed. The results showed after weeks of treatment that the animals gain weight instead of losing it and there were no benefcial effects of this remedy on lipid profle, in contrast there was an increase in LDL levels and decrease in HDL. The hisopathological study showed degeneration and necrosis in most organs , liver, kidney, spleen and gastrointestinal tract. Key words: obesity, weight loss, herbal treatment, AB slim, histopathology. Introduction The obesity in the world nowadays consider as a human public health problem which is leading to the death for women more than men in adults and children that have over weight (1) . There are many reasons for the obesity include gene and endocrine disorders, medications, or mental disorder (2) . Many people with health disorder be more acceptable to have over weight as psychiatric disorder patients and other (3) . The treatments of obesity mainly based on dieting and physical exercises, but the not considered diets may lead to hearts diseases and diabetes and many other disorders(4). Also the using of some plants may support the strategy for obesity control and weight management by enhancing the dominance of metabolic syndrome control (5) . The modern studies on the treatment of obesity have dedicated on the potential activity of plants to control obesity on the metabolism of lipid and glucose as green tea (6) . An enormous amount of herbal supplements are now present in the market and gyms for the controlling of obesity, even though they have not the same effect, reason being, supplements affecting different molecules thereby following distinctive mechanism of action varying completely from the other (7) . But the main action of these supplements focused on the receptors of the nervous system, by this means dealing with appetite and the metabolism of lipid and carbohydrate or caloric absorption or by increasing lipid excretion, increasing water removal, and improving mood (8) . Various supplements have not been studied and need more investigation to conclude effcacy and determine if supplements users vary from non-users with respect to their health outcomes when controlling for differences in diet quality. Further principles on production and marketing of these supplements would be needed (9) . AB slim is an traditional mixture of plants and herbs , it is used as a solution for the overweight problems and their complications. The aim of this study is to investigate about the effect of AB slim on metabolism in the body of its – takers and determine the safety of it.