ISSN: 2277- 7695 CODEN Code: PIHNBQ ZDB-Number: 2663038-2 IC Journal No: 7725 Vol. 2 No. 9 2013 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION - JOURNAL Vol. 2 No. 9 2013 www.thepharmajournal.com Page | 30 Cytogenetic Changes In The Hereditary Apparatus of Children of Early Age Suffering From Complicated Pneumonia Combined With Iron Deficiency Anemia Lyudmyla I. Haridzhuk 1* , Larysa Ye. Kovalchuk 2 1. Department of Children Diseases of Postgraduate Faculty, SHEI (state higher educational institution) “Ivano-Frankivsk national medical university” Ivano-Frankivsk, Ukraine 2. Department of Medical Biology and Genetics, SHEI (state higher educational institution) “Ivano-Frankivsk national medical university” Ivano-Frankivsk, Ukraine [Email: lyusic@ukr.net, Tel: +380958308201] Cytogenetic changes of the hereditary apparatus in children of early age suffering from complicated pneumonia combined with iron deficiency anemia have been studied. Using comparative analysis of changes in the genetic apparatus of children suffering from CP combined with IDA, we proved their dependence on the severity of anemia. We found an increase in the frequency of associations of aerocentric chromosomes and chromosomal aberrations in children with complicated pneumonia compared with control and dependence of these parameters on the severity of iron deficiency anemia. It has been established that chromosomes 21, 15 and 14 have the greatest ability to form associations, the lowest - 12 and 13 in each group of sick children. Among the types of chromosomal aberrations identified chromatic (single fragments), chromosomal (paired fragments isolated dicentrics and abnormal monocentrics), deletions and chromosome disruption. In the spectrum of chromosomal aberrations we proved the advantage of deletions of long arm of the 4 th and short arm of the 5 th and 6 th chromosomes. Keyword: Children, pneumonia, anemia, associations of acrocentric chromosomes. 1. Introduction Pneumonia is one of the urgent problems of child pulmonology due to its high prevalence and mortality. Particularly noteworthy are cases of pneumonia course with aggravated premorbid background or accompanying pathology [1, 2] . Among many factors that may complicate pneumonia course is iron deficiency. In recent years there has been an increase in the number of patients with pneumonia among children of early age, occurring in combination with iron deficiency anemia (IDA) [2] . One of the least covered aspects of the problem still remains cytogenetic homeostasis in above mentioned combined pathology. Currently, connection between changes in chromosomal apparatus of cell and inflammation has been established [5, 6, 9] . In particular, increase of chromosomal rearrangement in such inflammatory bronchopulmonary diseases as chronic bronchitis, bronchial asthma, acute pneumonia has already been described in literature [5, 11] . Among factors that violate genetic stability in inflammation of bronchi and lungs, are the following: influence of infection, including direct cytogenetic effect of viruses and indirect effects of bacterial and viral agents, increased release of inflammatory mediators, quantitative and functional deficiency of cellular link of immunity. However, relationship of cause and effect between inflammatory process and cytogenetic alteration are not completely understood. In this regard, we Received: 27-07-2013 Accepted: 09-09-2013