www.wjpps.com Vol 4, Issue 05, 2015. 1516 Halli et al. World Journal of Pharmacy and Pharmaceutical Sciences ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF A SCHIFF BASE AND ITS METAL COMPLEXES DERIVED FROM 3-AMINO-5- BROMOBENZOFURAN-2-CARBOXAMIDE - SYNTHESIS AND CHARACTERIZATION M. B. Halli*., Sadu Suryakant S and Mallikarjun Kinni Department of Chemistry, Gulbarga University, Kalaburagi [Karnataka] India-585106. ABSTRACT New metal complexes of Co(II), Ni(II), Cu(II) Zn(II) Cd(II ) and Hg(II) were synthesized from a Schiff base (L) formed by the condensation of 3-amino-5-bromobenzofuran-2- carboxamide and 2- hydroxy-5-(phenyldiazenyl)benzaldehyde. Newly synthesized metal complexes subjected to various spectral characterization and screened for their antibacterial and antifungal activities. Investigation of their biological activities shows that complexes are more active than its corresponding ligand. KEYWORDS: Schiff base, Metal Complexes, Spectral studies, Biological activity. INTRODUCTION Schiff bases of benzofuran and its derivatives attracted the chemists worldwide due to their easy synthesis, high stability and having excellent chemical, biological andpharmaceutical properties such as antibacterial and antifungal. [1] DNA cleavage, antioxidant properties .[2] Besides this Schiff base have also fluorescence properties. [3] The fast development in the field of coordination chemistry has been dominating among the research field in inorganic and bioinorganic chemistry. In recent years, several coordination compounds of transition and non-transition metal ions with a wide variety of legends having excellent biological and chemical properties have been reported. In view of the importance of the benzofuran Schiff base and its metal complexes in the animal kingdom and in continuation of our work on the study of Schiff base and their metal WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 5.210 Volume 4, Issue 05, 1516-1525. Research Article ISSN 2278 – 4357 Article Received on 11 March 2015, Revised on 02 April 2015, Accepted on 23 April 2015 *Correspondence for Author M. B. Halli Department of Chemistry, Gulbarga University, Kalaburagi [Karnataka] India-585106.