Title: A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155. Authors: Bushra Husain 1, , Sree R. Ramani 2 , Eugene Chiang 3 , Isabelle Lehoux 4 , Sairupa Paduchuri 1 , Tia A. Arena 5 , Ashka Patel 6 , Blair Wilson 7 , Pamela Chan 7 , Yvonne Franke 4 , Athena W. Wong 5 , Jennie R. Lill 1 , Shannon J. Turley 3 , Lino C. Gonzalez 1,6 , Jane L. Grogan 3 and Nadia Martinez-Martin 1, * Affiliations: 1 Microchemistry, Proteomics and Lipidomics Department, Genentech, South San Francisco, CA, USA. 2 Portfolio Management and Operations, Genentech, South San Francisco, CA, USA. 3 Cancer Immunology Department, Genentech, South San Francisco, CA, USA. 4 BioMolecular Resources, Genentech, South San Francisco, CA, USA. 5 Cell Culture, Genentech, South San Francisco, CA, USA. 6 23 & me Therapeutics, South San Francisco, CA, USA. 7 Biochemical Cellular Pharmacology, Genentech, South San Francisco, CA, USA. *Correspondence to: martinez-martin.nadia@gene.com Running title: New platform for receptor-ligand discovery Mol Cell Proteomics Papers in Press. Published on July 15, 2019 as Manuscript TIR119.001433 by guest on June 1, 2020 https://www.mcponline.org Downloaded from