European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 08, Issue 02, 2021 1565 Spontaneous esophageal rupture, report of 6 interesting cases Reza Afghani MD¹, Zahra Omrani MD², Roozbeh Cheraghali MD³ ¹: Thoracic Surgeon, Assistant proff. Of surgery, Golestan university of medical sciences,Gorgan,Iran af_med75@yahoo.com ²: General Surgeon: zahraomrani81@gmail.com, +989122769181 ³:Roozbeh Cheraghali MD(Corresponding author and post publication corresponding author) Assistant Professor of Surgery Vascular &Endovascular Surgery Golestan University of medical Sciences (GOUMS) Address:Sina Hospital,Hassan Abad Sq., Tehran 1136746911 ,Iran Tel:+98-21-66348564 Fax:+98-21-66348564 Roozbehcheraghali81@gmail.com, Dr.r.Cheraghali@goums.ac.ir Abstract: Spontaneous esophageal rupture is a rare clinical condition, occurs most often in the lateral, lower 1/3 of the esophagus and is associated with a mortality rate of 20–75%. As a result of these nonspecific findings, Spontaneous esophageal perforation is often misdiagnosed as an aortic emergency, pericarditis, myocardial infarction, pulmonary embolus, spontaneous pneumothorax, perforated peptic ulcer, or pancreatitis .We outline 6 cases of spontaneous esophageal perforation came to our institution and will discuss about their diagnosis ,required interventions ,complications and 2-year follow up. Keywords: Spontaneous esophageal rupture, case report, operation, follow up INTRODUCTION Spontaneous esophageal perforation is a rare clinical condition first described by the Dutch anatomist and physician Hermann Boerhaave in 1724. It represents 10-20% of esophageal ruptures and is defined as the spontaneous rupture of the total thickness of the esophageal wall