The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations Short title: False negative mutations in AML Margherita Bodini 1 , Chiara Ronchini 1 , Luciano Giacò 2 , Anna Russo 2 , Giorgio EM Melloni 1 , Lucilla Luzi 2,3 , Domenico Sardella 3,4 , Sara Volorio 3,4 , Syed K Hasan 5,6,7 , Tiziana Ottone 6,7 , Serena Lavorgna 6,7 , Francesco Lo-Coco 6,7 , Anna Candoni 8 , Renato Fanin 8 , Eleonora Toffoletti 8 , Ilaria Iacobucci 9 , Giovanni Martinelli 9 , Alessandro Cignetti 10 , Corrado Tarella 10 , Loris Bernard 2,4 , Pier Giuseppe Pelicci 2,11 * and Laura Riva 1 * 1 Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy 2 Department of Experimental Oncology, European Institute of Oncology, Milan, Italy 3 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy 4 Cogentech, Milan, Italy; 5 Department of Medical Oncology, Advanced Centre for Treatment, Research & Education in Cancer, Navi Mumbai, India 6 Department of Biomedicine and Prevention, University of ‘Rome Tor Vergata’, Rome, Italy 7 Laboratorio di Neuro-Oncoematologia, Fondazione Santa Lucia, Rome, Italy 8 Division of Hematology and Bone Marrow Transplantation, University Hospital, Udine, Italy 9 Institute of Hematology "Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy 10 University Division of Hematology and Cell Therapy, Mauriziano Hospital and University of Torino, Italy 11 Dipartimento di Scienze della salute, Università degli Studi di Milano, Milan, Italy *Corresponding authors. Blood First Edition Paper, prepublished online December 12, 2014; DOI 10.1182/blood-2014-05-576157 Copyright © 2014 American Society of Hematology For personal use only. on April 16, 2017. by guest www.bloodjournal.org From