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PRACA ORYGINALNA
52
CASE REPORT
Correspondence address: Correspondence address: Correspondence address: Correspondence address: Correspondence address: Krzysztof Gomulka M.D., Department of Internal Diseases, Geriatrics and Allergy, Medical University in Wroclaw, Traugutta St. 57/59,
50–417 Wroclaw, Poland, tel.: +48 71 733 2400, e-mail: kgomulka@wp.pl
Received on 08 August 2010
Copyright © 2011 Via Medica
ISSN 0867–7077
Krzysztof Gomułka
1
, Danuta Kuliczkowska
1
, Maria Cisło
2
, Zdzisław Woźniak
3
, Bernard Panaszek
1
1
Department of Internal Diseases, Geriatrics and Allergy, Medical University in Wrocław, Poland
Head: Prof. B. Panaszek M.D., Ph.D.
2
Department of Dermatology, Venereology and Allergy, Teaching Hospital No 1 in Wrocław, Poland
Head: Prof. E. Baran M.D., Ph.D.
3
Department of Pathology, Medical University in Wrocław, Poland;
Head: Prof. J. Rabczyński M.D., Ph.D.
Drug-induced hypersensitivity syndrome: a literature review and a
case report
Abstract
Drug-induced hypersensitivity syndrome (DIHS) is characterised by fever, rash and an involvement of the internal organs,
mainly the liver, myocardium, kidneys or lungs, which may develop within 1–8 weeks after exposure to the offending drug.
An increase in body temperature is generally the first sign, followed by erythematous skin eruptions, although the severity of
skin changes does not parallel the severity of internal organ involvement. It is believed that anti-epileptic drugs (particularly
carbamazepine), antibiotics and allopurinol are the commonest causes of DIHS. The pathomechanism of the syndrome is
unclear, although defects in the detoxification of reactive drug metabolites and genetic predisposition have been implicated.
The diagnosis of DIHS is based on the characteristic manifestations triggered by the drug and may be supported by
eosinophilia, elevated markers of inflammation and abnormal organ function tests, such as liver function tests. Management
involves immediate discontinuation of all suspected drugs and initiation of glucocorticosteroids. We report the case of a 72
year-old female who developed manifestations of DIHS after about four weeks of treatment with an anti-epileptic drug
(carbamazepine) for sensory axonal polyneuropathy. Discontinuation of the offending drug and initiation of systemic
glucocorticosteroids resulted in resolution of the clinical manifestations.
Key words: drug-induced hypersensitivity syndrome, carbamazepine, hepatitis
Pneumol. Alergol. Pol. 2011; 79, 1: 52–56
Introduction
Drug-induced hypersensitivity syndrome
(DIHS) is characterised by a skin rash, elevated
temperature and an involvement of the internal
organs (mainly the liver and kidneys) with a pro-
ved causal relationship between the drug and the
manifestations.
Bocquet et al. [cited in: 1–3] extended the de-
finition and introduced the term DRESS (drug rash
with eosinophilia and systemic symptoms). The
most commonly implicated drugs include anti-
epileptic drugs (mainly carbamazepine, phenyto-
in, phenobarbitol, lamotrigine), antibiotics (mino-
cycline, b-lactams, sulfonamides), antiviral agents
(abacavir, nevirapine), dapsone, sulfasalazine, and
allopurinol [3–6].
Callot et al. [cited in: 7] observed DIHS follo-
wing treatment with diltiazem and mexiletine. The
pathomechanism of the syndrome is unclear, al-
though it is arbitrarily assumed that the drug-in-
duced manifestations are associated with cytochro-
me P450 dysfunction and the presence of biologi-
cally reactive drug metabolites in the circulation
[5, 7]. These metabolites may activate macropha-
ges, eosinophils and T cells, which results in the
release of cytokines, mainly IL-5 [3, 4]. Recent bi-
bliographical data also suggests a possible reacti-
vation of certain viruses in the course of DIHS,
such as herpesvirus (HHV-6, HHV-7), Epstein-Barr
virus (EBV) or cytomegalovirus (CMV), which is
associated with the replication of viral DNA by the
stimulated immunocompetent cells [2–5, 8]. The
first manifestations of DIHS usually develop wi-