Research Article The Association of CReactive Protein Levels in Second Trimester of Pregnancy with Preeclampsia Hubungan Kadar CReactive  Protein pada Kehamilan Trimester II dengan Preeklamsia Zulfaekasari Nasruddin, Efendi Lukas, Umar Malinta, Maisuri T Chalid Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar INTRODUCTION The three major causes of maternal mortality in Indonesia are bleeding (30%), eclampsia (25%) and infection (12%). The World Health Organiza- tion (WHO) estimated that the rate of preeclampsia were seven times higher in developing countries compared to developed countries. The prevalence of preeclampsia in developed countries ranges from 1.3% to 6%, while in developing countries from 1.8% to 18%. The incidence of preeclampsia in Indonesia is 128 273 per year, or 5.3%. 1 During the last 8 years (from 2005 to 2013), the incidence of severe preeclampsia tends to increase at Dr. Wahidin Sudirohusodo Hospital. The incidence of severe preeclampsia in 2005-2007 by 8%, rising to 8.6% in the period 2007-2009, then in 2009-2011 increased by 13.47% and in the period of 2011-2013 the incidence up to 16.51%. 2 Preeclampsia is best described as a special- pregnancy syndrome involving multiorgan systems. 3,4 In the past, preeclampsia could be diagnosed whenever we found its clinical triad i.e, Abstract Objective: To determine C-reactive protein in second trimester of pregnancy women who preeclamptic and non-preeclamptic women, and to determine the relationship between the level of C-Reactive protein of trimester two pregnancy and preeclamp- sia occurrence. Methods: This was a prospective study conducted at the policlinics of network of academic hospitals of the Department of Obstetrics and Gynecology of Faculty of Medicine, Universitas Hasanuddin and policlinic of child and mother, and some Public Health Centers in Makassar city from September 2015 - April 2016. The C-reactive protein 115 level of pregnant women in pregnancy age of 24-28 weeks was checked, whether the subjects underwent preeclampsia until the childbirth process. Statistics analysis used Fisher’s exact test and Mann Whitney test. Results: The result indicate that 9 subjects (7.8%) developed preeclampsia and 106 subjects did not become preeclampsia. The level of C-Reactive protein increased in preeclampsia group com- pared to non preeclampsia group i.e 5.05  1.153 : 3.36  0.265, but statistically the result is not significant (value p>0.05). Conclusion: The average score of C-Reactive protein of pre- eclampsia group is 33.5% higher than non-preeclampsia group, even though these results cannot be used as the score to predict the preeclampsia occurrence. [Indones J Obstet Gynecol 2018; 6-1: 18-22] Keywords: C-reactive protein, preeclampsia, second trimester pregnancy Abstrak Tujuan: Mengetahui kadar C-Reactive Protein perempuan hamil trimester dua yang menjadi preeklamsia dan bukan preeklam- sia, serta mengetahui hubungan antara kadar C-Reactive Pro- tein kehamilan trimester dua dengan kejadian preeklamsia. Metode: Penelitian ini menggunakan rancangan kohort prospektif, di- laksanakan di Poliklinik RS jejaring pendidikan Departemen Obstetri dan Ginekologi FK UNHAS dan Poliklinik Kesehatan Ibu dan Anak dan beberapa Puskesmas Kota Makassar selama September 2015 - April 2016. Dilakukan pemeriksaan kadar C-Reactive Protein 115 ibu hamil pada usia kehamilan 24 - 28 minggu, kemudian diamati apakah sub- jek mengalami preeklamsia hingga proses persalinan. Analisis statistik menggunakan uji Fisher’s exact dan uji Mann Whitney. Hasil: Didapatkan hasil 9 subjek (7,8%) berkembang menjadi preeklamsia dan 106 subjek tidak menjadi preeklamsia. Terjadi peningkatan kadar C-Reactive Protein pada kelompok preeklamsia dibanding kelompok bukan preeklamsia yaitu 5,05  1,153 : 3,36  0,265 tapi hasilnya tidak bermakna secara statistik (nilai p>0,05). Kesimpulan: Nilai rerata kadar C-Reactive Protein kelompok pre- eklamsia 33,5% lebih tinggi dibandingkan dengan kelompok bukan preeklamsia, namun hasil ini belum dapat digunakan sebagai nilai untuk memprediksi kejadian preeklamsia. [Maj Obstet Ginekol Indones 2018; 6-1: 18-22] Kata kunci : C-Reactive Protein, kehamilan trimester dua, preeklamsia Correspondence: Zulfaekasari Nasruddin; zulfaekasari@gmail.com Indones J 18 Nasruddin et al Obstet Gynecol