_____________________________________________________________________________________________________ *Corresponding author: E-mail: cl.biochem@gmail.com; International Journal of Biochemistry Research & Review 16(1): 1-8, 2017; Article no.IJBCRR.31935 ISSN: 2231-086X, NLM ID: 101654445 SCIENCEDOMAIN international www.sciencedomain.org Hepatic Involvement with Elevated Liver Enzymes in Nepalese Subjects with Type 2 Diabetes Mellitus Nirajan Shrestha 1,2 , Nirmal Prasad Bhatt 1,3 , Puja Neopane 4 , Sudimna Dahal 5 , Prashant Regmi 5 , Madhav Khanal 5 and Rojeet Shrestha 6* 1 Department of Medical Biochemistry, Nobel College, Kathmandu, Nepal. 2 Laboratory of Liver Regeneration, Chonbuk National University, South Korea. 3 Department of Pharmacology, Kangwon National University, South Korea. 4 Health Sciences University of Hokkaido, Tobetsu, Japan. 5 Department of Clinical Biochemistry, Nepal Medical College, Kathmandu, Nepal. 6 Faculty of Health Sciences, Hokkaido University, Sapporo, Japan. Authors’ contributions This work was carried out in collaboration between all authors. Author RS designed the study. Authors NS and RS wrote the first draft of the manuscript. Authors PR and PN performed the statistical analysis and authors NS and NPB wrote the protocol. Authors NS, MK, NPB and RS managed literature searches. Authors NS, NPB and SD managed the specimen collection and laboratory analyses of the study. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IJBCRR/2017/31935 Editor(s): (1) Noureddine Benkeblia, Department of Life Sciences, The University of the West Indies, Jamaica. Reviewers: (1) Lorna T. Enerva, Polytechnic University of the Philippines, Philippines. (2) Anthony E. Ojieh, Delta State University, Abraka, Nigeria. (3) Atanas Baltadjiev, Medical University-Plovdiv, Bulgaria. Complete Peer review History: http://www.sciencedomain.org/review-history/18188 Received 31 st January 2017 Accepted 6 th March 2017 Published 14 th March 2017 ABSTRACT Background: Diabetes mellitus (DM) is characterized by a broad disturbance in metabolism. Since the liver plays a vital role in the regulation of metabolism, there is evidence of liver dysfunction in DM. There is a high prevalence of non-alcoholic fatty liver disease among diabetic patients in western countries. However, there is a paucity of data showing of such association in Nepalese patients with DM. Therefore, the present study was carried out for a better understanding of alteration of liver function in patients with type 2 DM (T2DM). Methods: A total of 105 patients (age between 30-74 years, male/female ratio=0.6), newly Original Research Article