33 Saturday, September 24, 2016 PSTM Abstract Supplement Surgery. Plastic and Reconstructive Surgery 2007, 119:2219 - 2227. 2. Stern CS, Schreiber JE, Surek CL, Garfein ES, Jelks EB, Jelks GW, Tepper OM: 3D Topographical Surface Changes in Response to Compartmental Volumization of the Medial Cheek; Defining a Malar “Augmentation Zone”. Plast Reconstr Surg 2016. Characterizing Fat in the Superficial and Intermediate Layers of the Neck: Analyzing Variations with Age using Volumetric Computed Tomography Susan Orra, MD; Kashyap Tadisina, MD; Adeeb Derakhshan, BS; Sandra Halliburton, PhD; Gaby Doumit, MD, MSc; James Zins, MD DISCLOSURE/FINANCIAL SUPPORT: Authors have no disclosures. INTRODUCTION: Fat compartment distribution plays an important role in the aging process of the neck, yet the spe- cifics of this process are largely unknown. This study uti- lizes volumetric computed tomography in live patients to characterize the fat compartments of the neck and examine how they change with respect to age. MATERIALS AND METHODS: Neck CT angiography was obtained for 20 “young” (age 20–35 years old) and 20 “elderly” (age 65 – 89 years old) females. The volume of neck fat in the supra and subplatysmal planes were quanti- fied. Distribution of fat volume was assessed by dividing each supra and sub platysmal compartments into upper, middle, and lower thirds. RESULTS: Total supraplatysmal fat volume was signifi- cantly greater than subplatysmal volume within both the “young” and “elderly”; however, “young” had significantly more total supraplatysmal fat than “elderly” (p<0.0001). There was no significant difference in fat volume between each third of the neck in the supraplatysmal compartment in “young”. The middle third of the supra-platysmal fat vol- ume in the “elderly” (28.58 ± 20.01 cm 3 ) was significantly greater than the upper (18.93 ± 10.35 cm 3 ) and lower thirds (15.46 ± 11.55 cm 3 ) respectively (p<0.01). There was no significant difference between the total sub-platysmal fat volume between the young and the elderly groups (p>0.05). CONCLUSION: We demonstrate that total supra-platys- mal fat volume significantly decreases with age. In addition, the elderly have significantly more fat volume in upper and middle thirds of the supra-platysmal neck, whereas young females have more evenly distributed fat volume between the three regions of the neck. This seems to be consistent with the observation of the elderly experiencing fat volume loss and subsequent “deflation” of the skin, causing skin laxity and vertical bands of the neck. A Prospective, Within-Subject Controlled Study of the Safety of Allograft Adipose Tissue Injections into the Hypodermis of Healthy Adults Athleo L. Cambre, MD; John H. Joseph, MD DISCLOSURE/FINANCIAL SUPPORT: Neither author has a financial interest in the product mentioned in this manuscript. INTRODUCTION: Autologous fat transfer (AFT) has been used for years as a permanent filling option for soft tissue defects. There are several challenges related to AFT such as overfilling, unpredictable resorption, and donor site morbid- ity. An allograft adipose-derived filler with native growth factors bound to the extracellular matrix to encourage angio- genesis and adipogenesis can be used as an alternative to AFT. In this study we evaluated the safety of allograft adipose tissue injections into the hypodermis of healthy adults who are scheduled for elective body reduction surgery. MATERIALS AND METHODS: An ongoing pro- spective, within-subject controlled study of the safety of allograft adipose tissue injections into the hypodermis was conducted. All subjects planned to undergo elective body reduction surgery to areas such as the arms, legs, or abdo- men in ≥ 30 to ≤180 days and received allograft adipose injections into an area of hypodermis intended for surgical excision. Similar tissue from the subject’s contralateral side served as the control. The subjects rated pain on an 11-point scale and completed a 14-day safety diary beginning on the evening of treatment to report any injection site responses. When the planned elective body reduction surgery was per- formed, the area treated with allograft adipose tissue injec- tions was surgically excised and a biopsy of the treated area was sent for histopathology examination. Similar tissue on the contralateral control side which was not injected was