DMD #31179 1 METABOLISM OF INTRAVENOUS METHYLNALTREXONE IN MICE, RATS, DOGS AND HUMANS Appavu Chandrasekaran, Zeen Tong, Hongshan Li, John C. L. Erve, William DeMaio, Igor Goljer, Oliver McConnell, Yakov Rotshteyn, Theresa Hultin, Rasmy Talaat and JoAnn Scatina Pharmacokinetics, Dynamics and Metabolism (A.C., Z.T., H.L., J.E., W.D., T.H., R.T., J.S.) and Discovery Analytical Chemistry (I.G., O.M.), Pfizer, 500 Arcola Road, Collegeville, PA 19426 and Progenics Pharmaceuticals, Inc. (Y.R.), 777 Old Saw Mill River Road, Tarrytown, NY 10591 DMD Fast Forward. Published on January 6, 2010 as doi:10.1124/dmd.109.031179 Copyright 2010 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on January 6, 2010 as DOI: 10.1124/dmd.109.031179 at ASPET Journals on January 10, 2022 dmd.aspetjournals.org Downloaded from