© 2020, IJPBA. All Rights Reserved 65 Available Online at www.ijpba.info International Journal of Pharmaceutical & Biological Archives 2020; 11(2):65-70 ISSN 2582 – 6050 REVIEW ARTICLE Novel Antihypertensive Drug Used in Clinical Practice: A Review Sanjay Bais 1 *, Sarfaraz Kazi 2 , Sajid Shaikh 3 1 Department of Quality Assurance, Fabtech College of Pharmacy, Sangola, Solapur, Maharashtra, India, 2 Department of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India, 3 Department of Pharmacology, Vedprakash Patil College of Pharmacy, Georai Tanda, Aurangabad, Maharashtra, India Received: 01 February 2020; Revised: 01 March 2020; Accepted: 01 April 2020 ABSTRACT Introduction: Blood pressure (BP) control continues to be important in reducing cardiovascular risk, along with the modifcation of other cardiovascular risk factors, especially cholesterol level. Lifestyle modifcation to reduce BP may control Stage 1 hypertension. Drug treatment should be based on evidence of improved outcomes and individualized account for the patient age, race, and quality of life. BP varies from minute to minute and is infuenced by measurement technique, time of day, emotion, pain, discomfort, hydration, temperature, exercise, posture, and drugs. Purpose of Review: In this review, we examine how synthetic novel drugs involved in the management of hypertension not only in the wider population but also within special population groups such as the elderly, pregnant women, and those with a trial fbrillation. Conclusion: The extensive synthetic work carried out shows that some molecules are very effectively managing the hypertension in all ages of patients. Summary: We have made an attempt in reviewing the literature on 1,2 pyrazoline derivatives for their medicinal uses with the help of chemical abstract, journals, and internet surfng. Keywords: Blood pressure, clinical management, hypertension, synthetics drugs *Corresponding Author: Dr. Sanjay Bais E-mail: sanjaybais1968@gmail.com INTRODUCTION Blood pressure (BP) control continues to be important in reducing cardiovascular risk, along with the modifcation of other cardiovascular risk factors, especially cholesterol level. Lifestyle modifcation to reduce BP may control Stage 1 hypertension. Drug treatment should be based on evidence of improved outcomes and individualized account for patient age, race, and quality of life. Although the number of cardiovascular deaths has decreased over the past 25 years, achieving long- term control of hypertension in millions of patients remains an important objective. BP varies from minute to minute and is infuenced by measurement technique, time of day, emotion, pain, discomfort, hydration, temperature, exercise, posture, and drugs. The dividing line between normal BP and hypertension is arbitrary. [1,2] According to the Joint National Committee VI, hypertension is when the diastolic BPs measurement is 90 mm Hg or higher, and systolic BPs measurement is consistently >140 mm Hg. [3] Hypertension remains one of the largest unmet medical needs in the 21 st century, especially when one considers that hypertension is the potent of future debilitating cardiovascular disease. [1] The interrelation of a number of regulatory factors to control BP and tissue perfusion was frst described by page in 1949. According to this concept, tissue perfusion/ pressure/resistance are interdependent on factors designated chemical, reactivity, volume, vascular caliber, viscosity, cardiac output, elasticity, and multifactorial derangement of normal equilibrium. [4] The baroreceptors, mainly in the walls of the aorta and the internal carotid arteries, act on rapidly adjust to changes in pressure (stretch) response time in seconds. This is accomplished by activation of afferent nerves from the baroreceptors