Case Report Section Paper co-edited with the European LeukemiaNet Atlas Genet Cytogenet Oncol Haematol. 2011; 15(9) 806 Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS A new case of translocation t(14;14)(q11;q32) in B lineage ALL Elvira D Rodrigues Pereira Velloso, Priscila Pereira dos Santos Teixeira, Karina Prandi Melillo, Luciana J Rodrigues da Silva, Cristina Alonso Ratis, Daniela Borri, Cristóvão LP Mangueira Clinical Laboratory, Hospital Israelita Albert Einstein, Sao Paulo, Brazil (EDRPV, PPdST, LJRdS, CAR, DB, CLPM); CASE Intermedica, Sao Paulo, Brazil (KPM) Published in Atlas Database: February 2011 Online updated version : http://AtlasGeneticsOncology.org/Reports/t1414BALLVellosoID100048.html DOI: 10.4267/2042/46023 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology Clinics Age and sex 43 years old male patient. Previous history no preleukemia ; no previous malignancy ; no inborn condition of note. Organomegaly hepatomegaly , splenomegaly , no enlarged lymph nodes , central nervous system involvement. Blood WBC : 227X 10 9 /l HB : 5,9g/dl Platelets : 51X 10 9 /l Blasts : 12% Bone marrow : aspirate: 90% lymphoblast% Cyto-Pathology Classification Cytology LLA-L2 Immunophenotype HLA-DR+, TdT+, CD79a+, CD19+, cyCD22+, CD20+, CD10+ Rearranged Ig Tcr rearranged IGH (FISH) Pathology not done Electron microscopy not done Diagnosis common B-ALL Survival Date of diagnosis: 02-2009 Treatment: Cancer and Leukemia Group B (CALGB) protocol Complete remission : not evaluated Treatment related death : Neutropenia and lung infection Relapse : no Status: Death. Last follow up: 03-2009 Survival: 20 days Karyotype Sample: Bone marrow Culture time: 24 and 48 hours without stimulating agents Banding: G Results: 46,XY,t(14;14)(q11;q32.1)[20] Karyotype at Relapse: not done Other molecular cytogenetics technics FISH using IGH Break Apart Rearrangement Probe, Vysis Other molecular cytogenetics results nuc ish(IGHx2)(5'IGH sep 3'IGHx1)[154/200]/ (5'IGHx2,3'IGHx1)(5'IGH con 3'IGHx1)[33/200]