*Corresponding author: Ali Ramazani *, Email: aliramazani@gmail.com, aliramazani@znu.ac.ir page 78 of 98 Journal of Chemical Reviews, 2019, volume:1, Issue:2, pages: 78-98. Plants of the Genus Heracleum as a Source of Coumarin and Furanocoumarin Receive Date: 31 January 2018, Revise Date: 15 February 2018, Accept Date: 22 February 2018 Abstract: Heracleum is one of the greatest genera of the Umbelliferae family that has more than 120 species. This genus is represented by 109 species in Asia. Common names for the genus or its species include hogweed and cow parsnip. This paper discusses the phytochemistry, ethnopharmacological use and pharmaceutics of Heracleum species. Many kinds of metabolites have been isolated and identified, that furanocoumarins are among the significant ones. Modern pharmacological studies demonstrated that Heracleum and its active compounds have extensive biological activity, particularly in anticonvulsant, anti- inflammatory, antifungal, anticancer, anti-psoriatric, anti-vitiligo and antioxidant activities. In clinical test, Heracleum has successfully been utilized to treat psoriasis, vitiligo, carminative, stomachs, pain killer and anticonvulsant. Keywords: Heracleum, furanocoumarins, coumarins, anticovulsant, anti-inflammatory. Graphical Abstract: Zahra Hosseinzadeh a , Ali Ramazani a,b * and Nima Razzaghi-Asl c a Department of Chemistry, University of Zanjan, Zanjan, Iran b Research Institute of Modern Biological Techniques, University of Zanjan, P O Box 45195-313 c Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran Review Article