Agrawal et al Journal of Drug Delivery & Therapeutics. 2020; 10(5-s):224-228 ISSN: 2250-1177 [224] CODEN (USA): JDDTAO Available online on 15.10.2020 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Review Article Solid Lipid Nanoparticle for the Delivery of Docetaxel: A Review Agrawal Pranav*, Tatode Amol, Umekar Milind Smt. Kishroitai Bhoyar College of Pharmacy, Department of Pharmaceutics, Kamptee, Nagpur, Maharashtra, India-441002 ABSTRACT Solid lipid nanoparticles are the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research. Due to its solid state it has greater stability than other nanocarrier systems. There are several other advantages like sustained release, improves bioavaibility and delivery of poorly water soluble drugs, helps in control of several pharmacokinetic parameters of drugs due to which use of SLN is increasing day by day. Various techniques can be used for the formulation of SLN i.e. solvent evaporation, microemulsification technique, high pressure homogenization and supercritical fluid method. It has several applications likes it is use in gene transfer therapy, also use in different drug delivery systmer like oral and pulmonary drug delivery system. Due to several advantages SLNs are widely used in chemotherapy for the treatment of the cancer. The use of SLN for the delivery of Docetaxel to tumor site have several benefits likes site specific delivery, less toxic effect, more cell cytotoxicity and more bioavaibility which leads to decrease in the dosing frequency. Docetaxel is an anticancer agent extracted from plant Taxus Baccata which is widely used in chemotherapy to treat cancer. This article contains the detail information of about the advantages, disadvantages, different method of preparation and several SLN loaded with Docetaxel. Keywords: Solid lipid nanoparticles, drug delivery, clinical medicine, poorly water soluble drugs Article Info: Received 10 Aug 2020; Review Completed 15 Sep 2020; Accepted 23 Sep 2020; Available online 15 Oct 2020 Cite this article as: Agrawal P, Tatode A, Umekar M, Solid Lipid Nanoparticle for the Delivery of Docetaxel: A Review, Journal of Drug Delivery and Therapeutics. 2020; 10(5-s):224-228 http://dx.doi.org/10.22270/jddt.v10i5-s.4441 *Address for Correspondence: Agrawal Pranav, Smt. Kishroitai Bhoyar College of Pharmacy, Department of Pharmaceutics, Kamptee, Nagpur, Maharashtra, India-441002 Introduction Colloidal particles ranging in size between 10 and 1000nm are known as nanoparticles. They are manufactured from synthetic or natural polymers and ideally suited to optimized drug delivery and reduce toxicity. Over the years, they have emerged as a variable substitute to liposome as drug carrier. The successful implementation of nanopartilces for drug delivery depends on their ability to penetrate across the cell membrane, sustained release of their contents and their stability 1 . There are several disadvantages of liposome or traditional nanoparticles like stability, leakage of drug from the dosage form, etc. to overcome these problem Solid lipid nanoparticles was developed. SLN are colloidal carriers developed in the last decade as an alternative system to existing traditional carrier such as emulsion, liposomes and polymeric nanoparticles. They are a new generation of submicron-sized lipid emulsion where the liquid lipid has been substituted by solid lipid. SLN offer unique properties such as small size, large surface area, high dose loading and the interaction of phases at the interfaces and are attractive for potential to improve performance of pharmaceuticals, neutraceuticals and other materials as well as increase stability is the most important advantage of SLN. SLN are sub-micron colloidal carrier which is composed of physiological lipid, dispersed in water or in an aqueous surfactant solution. The use solid lipid instead of liquid lipid is beneficial as it has been shown to increase control over the release kinetics of encapsulated compounds and to improve the stability of incorporated chemically-sensitive lipophilic ingredients. The benefit of using solid lipids is due to several physiochemical properties of lipid. Firstly, the mobility of reactive agents in solid matrix is lower than in a liquid matrix and so the rate of chemical degradation reactions may be retarded. Secondly, micro phase separations of the active ingredients and carrier lipid within individual liquid particles can be controlled, thereby preventing the accumulation of active compounds at the surface of lipid particles where chemical degradation reactions often occur. There is also another benefit; the absorption of poorly absorbed drugs has been shown to be increased after incorporation into solid lipid nanoparticles 2 . Due to several benefits SLN are used for various types of drugs like antineoplastic agents, delivery of several protein and peptide, antiepileptic agents, etc. Cancer is one of the