Ms. No. EJPS-D-15-01052R3 – 20 June 2016 Phenothiazines solution complexity – determination of pK a and solubility-pH profiles exhibiting sub- micellar aggregation at 25 and 37 o C Aneta Pobudkowska a,* , Clara Ràfols b , Xavier Subirats b , Elisabeth Bosch b , Alex Avdeef c a Department of Physical Chemistry, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland; b Departament de Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona, Martí i Franquès 1-11, E-08028 Barcelona, Spain; c in-ADME Research, 1732 First Avenue #102, New York, NY 10128, USA. * Corresponding author: Tel.: +48 22 234 74 75; fax: +48 22 628 27 41. E-mail address: pobudka@ch.pw.edu.pl (A. Pobudkowska).