healthcare Case Report From Child to Adulthood, a Multidisciplinary Approach of Multiple Microdontia Associated with Hypodontia: Case Report Relating a 15 Year-Long Management and Follow-Up Charlotte Thomas 1,2,3 , Frédéric Vaysse 2,4,5 , Teva Courset 2,3 , Karim Nasr 2,6 , Bruno Courtois 2,3,7 , Arnaud L’Homme 3,6 , Nicolas Chassaing 5,8 , Alexia Vinel 1,2,3 , Isabelle Bailleul-Forestier 2,4,5 , Luc Raynaldy 3,5,9,† and Sara Laurencin-Dalicieux 1,2,3,5, * ,†   Citation: Thomas, C.; Vaysse, F.; Courset, T.; Nasr, K.; Courtois, B.; L’Homme, A.; Chassaing, N.; Vinel, A.; Bailleul-Forestier, I.; Raynaldy, L.; et al. From Child to Adulthood, a Multidisciplinary Approach of Multiple Microdontia Associated with Hypodontia: Case Report Relating a 15 Year-Long Management and Follow-Up. Healthcare 2021, 9, 1180. https:// doi.org/10.3390/healthcare9091180 Academic Editor: Saturnino Marco Lupi Received: 28 July 2021 Accepted: 2 September 2021 Published: 8 September 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil- iations. Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). 1 Periodontology Department, CHU Toulouse, 31062 Toulouse, France; thomas.ch@chu-toulouse.fr (C.T.); vinel.a@chu-toulouse.fr (A.V.) 2 Toulouse School of Dental Medicine, Paul Sabatier University, CEDEX 9, 31062 Toulouse, France; vaysse.f@chu-toulouse.fr (F.V.); tevac@hotmail.fr (T.C.); karnasr@gmail.com (K.N.); brunocourtois.co@gmail.com (B.C.); isabelle.bailleul-forestier@univ-tlse3.fr (I.B.-F.) 3 Oral Surgery and Rehabilitation Unit (UCOR), CHU Toulouse, 31062 Toulouse, France; arnaud-lhomme@hotmail.fr (A.L.); raynaldy.l@chu-toulouse.fr (L.R.) 4 Paediatric Department, CHU Toulouse, 31062 Toulouse, France 5 Competence and Reference Center for Rare Oral Diseases (CCMR O-Rare), CHU Toulouse, 31062 Toulouse, France; chassaing.n@chu-toulouse.fr 6 Biomaterial Department, CHU Toulouse, 31062 Toulouse, France 7 Oral Surgery Department, CHU Toulouse, 31062 Toulouse, France 8 Department of Medical Genetics, CHU Toulouse, 31059 Toulouse, France 9 Prosthodontics Department, CHU Toulouse, 31062 Toulouse, France * Correspondence: laurencin.s@chu-toulouse.fr; Tel.: +33-5-61-32-20-30 or +33-5-61-77-36-10 † Equal contribution. Abstract: Oral rehabilitation of patients presenting multiple microdontia is a real therapeutic chal- lenge. These alterations in size, often associated with other dental anomalies, have aesthetic and functional repercussions for patients and can lead to significant psycho-social consequences. We report here the case of an 11-year-old patient with bilateral sectorial microdontia and agenesis of teeth numbers 13 and 23. She also presented staturo-ponderal delay and a history of acute coronary syndrome with a lower coronary occlusion of unknown aetiology. At first, additive coronoplasties and an orthodontically retained interim prosthesis answered the aesthetic and functional need during childhood and adolescence. Once she reached adulthood, a multidisciplinary meeting was conducted and a treatment plan was established. The decision was made to rehabilitate the upper arch with a permanent bridge and the lower arch with indirect adhesive restorations. This solution solved the problem of the bilateral lateral infraocclusions and tooth agenesis, restoring both aesthetics and function. This paper presents 15 years of management and treatment of a patient presenting multiple microdontia associated with hypodontia. Both the multidisciplinary approach and coordination between the different medical team members was essential to maintain the existing dentition while preparing, planning, and carrying out a personalized treatment plan once maxillofacial growth was complete. Keywords: microdontia; hypodontia; prosthetics; multidisciplinary treatment; oral rehabilitation 1. Introduction Microdontia is a type of dental anomaly in which teeth are abnormally small. Different types of microdontia exist. They can affect a single tooth or the entire denture and both primary and permanent teeth. Other dental anomalies such as hypodontia may also be associated with microdontia [1]. These alterations in size may be linked to genetic factors and in particular syndromes such as pituitary dwarfism and Rieger’s syndrome. They can Healthcare 2021, 9, 1180. https://doi.org/10.3390/healthcare9091180 https://www.mdpi.com/journal/healthcare