xi Biochemical Journal Volume 333, part 3 1 August 1998 Review Articles Chemokines : understanding their role in T-lymphocyte biology by S.G. Ward and J. Westwick 457–470 Phosphoinositide 3-kinase : the key switch mechanism in insulin signalling by P.R. Shepherd, D.J. Withers and K. Siddle 471–490 Research Communication Characterization of human and rat brain myristoyl-CoA : protein N-myristoyltransferase : evidence for an alternative splice variant of the enzyme R.A.J. McIlhinney, K. Young, M. Egerton, R. Camble, A. White and M. Soloviev 491–496 Research Papers Proteins Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases A.L. Wilson, R.A. Erdman, F. Castellano and W.A. Maltese 497–504 Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque S. Fu, M.J. Davies, R. Stocker and R.T. Dean 519–525 Evaluation of the stoichiometry and energetics of carbohydrate binding to Ricinus communis agglutinin : a calorimetric study S. Sharma, S. Bharadwaj, A. Surolia and S.K. Podder 539–542 Orientation of sugars bound to the principal C-type carbohydrate- recognition domain of the macrophage mannose receptor P.G. Hitchen, N.P. Mullin and M.E. Taylor 601–608 Enzymes CD23 (FcεRII) release from cell membranes is mediated by a membrane-bound metalloprotease A.E. Marolewski, D.R. Buckle, G. Christie, D.L. Earnshaw, P.L. Flamberg, L.A. Marshall, D.G. Smith and R.J. Mayer 573–579 Mutational analysis of the two ATP-binding sites in ClpB, a heat shock protein with protein-activated ATPase activity in Escherichia coli K.I. Kim, K.M. Woo, I.S. Seong, Z.-W. Lee, S.H. Baek and C.H. Chung 671–676 Tyrosinase kinetics : failure of the auto-activation mechanism of monohydric phenol oxidation by rapid formation of a quinomethane intermediate C.J. Cooksey, P.J. Garratt, E.J. Land, C.A. Ramsden and P.A. Riley 685–691 Amino acid sequence of glutathione S-transferase rGSTM5* from rat testis M.F. Tam, C.-H. Hsieh, S.-P. Tsai and T.-C.S. Tam 735–739 Purification and characterization of catechol 1,2-dioxygenase from Rhodococcus rhodochrous NCIMB 13259 and cloning and sequencing of its catA gene P.D. Strachan, A.A. Freer and C.A. Fewson 741–747 Herbicide-resistant forms of Arabidopsis thaliana acetohydroxyacid synthase : characterization of the catalytic properties and sensitivity to inhibitors of four defined mutants A.K. Chang and R.G. Duggleby 765–777 Sheep mast-cell proteinases-1 and -3 : cDNA cloning, primary structure and molecular modelling of the enzymes and further studies on substrate specificity S.M. McAleese, A.D. Pemberton, M.E. McGrath, J.F. Huntley and H.R.P. Miller 801–809 The three-dimensional structure of a class-Pi glutathione S-transferase complexed with glutathione : the active-site hydration provides insights into the reaction mechanism A. Pa  rraga, I. Garcı  a-Sa  ez, S.B. Walsh, T.J. Mantle and M. Coll 811–816 Glutathione S-transferases of the yeast Yarrowia lipolytica have unusually large molecular mass V. Foley and D. Sheehan 839–845