Solid Tumour Section Mini Review Atlas Genet Cytogenet Oncol Haematol. 2003; 7(3) 194 Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Bone: Giant cell tumour Ramses G Forsyth, Pancras CW Hogendoorn N. Goormaghtigh Institute of Pathology, University Hospital Ghent, B-9000 Gent, Belgium (RGF); Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands (PCWH) Published in Atlas Database: June 2003 Online updated version: http://AtlasGeneticsOncology.org/Tumors/BoneGiantCellTumID5150.html DOI: 10.4267/2042/37996 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2003 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity A characteristic well-defined eccentric, lytic subchondral lesion involving the epiphysis and metaphysis. The borders are well defined and usually not sclerotic. Pathologic fracture is present in 5-10% of giant cell tumours. Dynamic MRI shows a fast uptake and a slow wash out of contrast.