Polysaccharide–Aloe vera Bioactive Hydrogels as Wound Care System Surabhi Singh, Sadiya Anjum, Jincy Joy, and Bhuvanesh Gupta Contents 1 Introduction ................................................................................... 2 2 Polysaccharides and Bioactive Moieties ..................................................... 4 3 Aloe vera as Therapeutic Moiety ............................................................. 6 4 Chitosan–Aloe vera as the Wound Care Hydrogel .......................................... 10 5 Conclusion .................................................................................... 13 References ........................................................................................ 15 Abstract Wound care is an essential aspect of any trauma or surgical procedure. Designing an ideal wound healing system requires moist wound bed, proper exudate ab- sorption, optimal diffusion of gases and minimum microbial invasion at the wound site which play a pivotal role. Therefore, choice of an ideal wound dressing is an essential step toward it contributing to the acceleration of wound repair and regeneration as well as prevention from microbial infection. This chapter is dedicated to the development of polysaccharide (PS)-based hydrogels for wound care system by incorporating herbal bioactive agents such as aloe vera which would provide deep insights into the designing aspect of the dressing by incorporation of features of the natural system. The healing aspect and tissue regeneration by PS or its combination with other natural polymers and aloe vera are discussed in the chapter. S. Singh · S. Anjum · J. Joy · B. Gupta (*) Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi, India e-mail: bgupta@textile.iitd.ernet.in # Springer International Publishing AG, part of Springer Nature 2018 Md. I. H. Mondal (ed.), Cellulose-Based Superabsorbent Hydrogels, Polymers and Polymeric Composites: A Reference Series, https://doi.org/10.1007/978-3-319-76573-0_48-1 1