Cardiol Cardiovasc Med 2022; 6 (2): 206-216 DOI: 10.26502/fccm.92920256 Cardiology and Cardiovascular Medicine Vol. 6 No. 2 – April 2022. [ISSN 2572-9292] 206 Research Article Do Higher Plasma Omega-3 Levels Predispose to Prostate Cancer? Results from the Intermountain INSPIRE Biobank Registry Jeffrey L Anderson 1* , Viet T Le 2 , Mohit Jain 3 , Raymond O McCubrey 1 , Stacey Knight 1 , Daniel Bride 1 , Mahan Najhawan 3 , Khoi Dao 3 , Jeramie D Watrous 3 , Tami L Bair 1 , Benjamin D Horne 1,4 , Joseph B Muhlestein 1 , John F Carlquist 1 , Kirk U Knowlton 1 1 Intermountain Medical Center Heart Institute, Intermountain Healthcare, Salt Lake City, USA 2 Intermountain Medical Center Heart Institute, Rocky Mountain University of Health Professionals, Utah, USA 3 University of California San Diego, California, USA 4 Stanford University, Stanford, California, USA *Corresponding author: Jeffrey L Anderson, Intermountain Medical Center Heart Institute, Intermountain Healthcare, Salt Lake City, USA Received: 09 June 2021; Accepted: 23 June 2021; Published: 25 April 2022 Citation: Jeffrey L Anderson, Viet T Le, Mohit Jain, Raymond O McCubrey, Stacey Knight, Daniel Bride, Mahan Najhawan, Khoi Dao, Jeramie D Watrous, Tami L Bair, Benjamin D Horne, Joseph B Muhlestein, John F Carlquist, Kirk U Knowlton. Do Higher Plasma Omega-3 Levels Predispose to Prostate Cancer? Results from the Intermountain INSPIRE Biobank Registry. Cardiology and Cardiovascular Medicine 6 (2022): 206-216. Abstract Background: Omega-3 fatty acid supplements are widely used for cardiovascular (CV) prevention. However, a prominent report proposed that total and high-grade prostate cancer (PrCA) risk increased with increasing levels of docosahexaenoic acid (DHA) and trended to with eicosapentaenoic acid (EPA). Objective: Given public health implications, we prospectively tested this finding in the INSPIRE Registry. Methods: Plasma samples from men enrolled in the INSPIRE Registry who developed incident PrCA during follow-up were selected and matched ~2:1 with men of similar age and entry date who were free of PrCA