_____________________________________________________________________________________________________ *Corresponding author: E-mail: constinokob@gmail.com, obou.constantin@ujlg.edu.ci; International Journal of Biochemistry Research & Review 30(3): 11-17, 2021; Article no.IJBCRR.70146 ISSN: 2231-086X, NLM ID: 101654445 Effect of Naja nigricollis (Elapidae) Venom on Some Vital Organs of Oryctolagus cuniculus Obou Constantin Okou 1,2* , Djako Sosthène Thierry Akré 1 , Allali Eugène Koffi 1,2 , Guy Childeric Bingo 1 and Allico Joseph Djaman 2 1 Department of Biochemistry and Microbiology, Jean Lorougnon Guédé University, Côte d'Ivoire. 2 Department of Biology-Health, Félix Houphouët-Boigny University Abidjan, Côte d’Ivoire. Authors’ contributions All of the authors mentioned contributed to this work at their own level. Author OCO defined the theme and interpreted the results obtained. Authors DSTA and AEK read and corrected the manuscript. Author GCB created the conditions for animal rearing, organ harvesting and drafted the manuscript. Author AJD provided scientific support for the work. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IJBCRR/2021/v30i330255 Editor(s): (1) Dr. Muhammad Farhan Jahangir Chughtai, Nur International University and Khwaja Fareed University of Engineering & Information Technology, Pakistan. Reviewers: (1) Héctor Hugo Siliceo Cantero, National Autonomous University of Mexico, Mexico. (2) Daniel Ojochenemi Apeh, Kogi State University, Nigeria. (3) Nagham Mahmood Aljamali, Kufa University, Iraq. Complete Peer review History: https://www.sdiarticle4.com/review-history/70146 Received 05 May 2021 Accepted 10 July 2021 Published 13 July 2021 ABSTRACT The general objective of this study was to evaluate the effect of Naja nigricollis venom on some vital organs of rabbits. To carry out this study, nine (9) rabbits including five (5) males and four (4) females were divided into two (2) control lots and one (1) experimental lot. Each control lot was composed of three (3) rabbits (males or females) while the experimental lot was comprised of two (2) males and one (1) female. The rabbits of the experimental lot were injected with Naja nigricollis venom for about 20 to 30 minutes and then after the determination of their biochemical and hematological parameters, were autopsied for the removal of organs such as heart, liver, kidneys and lungs. These organs were weighed and their appearance was studied. The results of this study showed that the heart and lungs of control male rabbits weighed more than those of females, whereas the liver and kidneys did not. Then, the cytotoxins of the Naja nigricollis venom were at the origin of gangrene which induced necrosis by an increase in their volume in a general way and Original Research Article