_____________________________________________________________________________________________________ ≡ PhD Scholar; # Professor; † Assistant professor; *Corresponding author: E-mail: rbr.226@gmail.com; Journal of Pharmaceutical Research International 33(52B): 252-258, 2021; Article no.JPRI.76033 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Efficacy of Ayurveda Interventions Specifically on Weight Gain in the Management of Protein Energy Malnutrition in Children: A Systematic Review Protocol Sumod Khedekar a≡ , Renu Rathi a*# , Bharat Rathi b# , Heramb Hattikar c† , Suraj Patlekar c† and Avinash Karambhe d† a Department of Kaumarbhritya, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Salod (H). Wardha, Datta Meghe Institute of Medical Sciences, Wardha, India. b Department of Rasashastra, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Salod (H). Wardha, Datta Meghe Institute of Medical Sciences, Wardha, India. c Department of Shalakyatantra, Gomantak Ayurveda Mahavidyalaya and Research Centre, Shiroda- Goa, India. d Department of Kaumarbhritya, Bhausaheb Mulak Ayurveda College and Hospital Nagpur, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i52B33624 Editor(s): (1) Dr. Syed A. A. Rizvi, Nova Southeastern University, USA. Reviewers: (1) Maneesh P, KL University, India. (2) Parama Tirta W Wening Kusuma, National Research and Innovation Agency, Indonesia. Complete Peer review History, details of the editor(s), Reviewers and additional Reviewers are available here: https://www.sdiarticle5.com/review-history/76033 Received 18 September 2021 Accepted 23 November 2021 Published 02 December 2021 ABSTRACT Background: In India, Protein Energy Malnutrition (PEM)remains a significant and challenging public health issue despite implementing different nutritional policies over the period. It is also accompanying with aggravated risk of all-cause morbidity, as well as fatality Ayurveda mentions about various nutritional disorders such as karshya, balashosha, phakka, yakshma which are having similar symptomatology and treatment approach as that of the PEM. Several clinical studies Study Protocol