1 A human-specific modifier of cortical circuit connectivity and function improves behavioral performance Ewoud R.E. Schmidt 1,3 , Hanzhi T. Zhao 2,3 , Jung M. Park 1,3 , Jacob B. Dahan 1,3 , Chris C. Rodgers 1,3,4 , Elizabeth M. C. Hillman 2,3 , Randy M. Bruno 1,3,4 , and Franck Polleux 1,3,4 # 1 Department of Neuroscience 2 Department of Biomedical Engineering and Radiology 3 Mortimer B. Zuckerman Mind Brain Behavior Institute 4 Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA # Address correspondence to: Franck Polleux, Ph.D. Columbia University Department of Neuroscience Mortimer B. Zuckerman Mind Brain Behavior Institute Kavli Institute for Brain Science Jerome L. Greene Science Center 3227 Broadway L5-050, MC 9853 New York, NY 10027 fp2304@columbia.edu . CC-BY-NC-ND 4.0 International license available under a not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint (which was this version posted August 14, 2020. ; https://doi.org/10.1101/852970 doi: bioRxiv preprint