irregular or absent crypt pattern and disrupted architecture (p0.05). SC on TPI trended higher for all time points than NMI but did not reach statistical significance. SFI computed on all subbands was lowest for NM vs. NM and higher in NM vs. TPI, indicating differences in the structure and spatial distribution of the EGFR signal. Conclusion: In vivo imaging of vessels is a promising technique to characterize targeted receptors in colorectal cancer. Images can be interpreted both qualitatively and quantitatively to differentiate normal vs tumor. Further developments on the FNPA delivery may allow for a multifunctional imaging and treatment agent. Sa1618 EUS-Guided Translumenal Drainage of Pancreatic Fluid Collections Using a Novel Single-Step Access Device (NAVIX ™). Preliminary Experience Mariano Gonzalez-Haba Ruiz*, Vani J. Konda, Irving Waxman Center for Endoscopic Research and Therapeutics, University of Chicago Medical Center, Chicago, IL Introduction: Endoscopic drainage is now considered as an alternative to surgical or percutaneous drainage for pseudocysts, infected pseudocysts, and in selected cases of organized necrotizing pancreatitis. EUS-assisted drainage is widely preferred for its added safety and a more accurate pre-procedure assessment. However, this technique usually requires a sequential approach, with multiple steps and instrumental exchanges.A novel device enables a secured access, dilation of the tract and two wires placement in a single step approach. Aim: To assess feasibility and outcomes of this device (NAVIX™) for single step EUS guided drainage of pancreatic fluid collections(PFC). Methods: EUS-guided translumenal drainage in nine consecutive patients with PFC is reported.Using a transgastric or transduodenal approach, curved linear array echoendoscope with color Doppler was used to identify and access the fluid collection. The NAVIX access device (Xlumena Inc, Mountain View, CA) is composed by a 19G trocar capable to create a 3.5mm incision, which allows the passage of a two stages balloon (20mm anchor balloon to secure access and 10mm dilation balloon). Two guidewire ports permit the insertion of plastic stents up to 10F caliber. Aspiration of fluid can be performed. The trocar on the NAVIX was used to gain EUS-guided transenteric access into the collection. The balloon catheter was advanced directly over the trocar and theanchor balloon component was inflated. The tract was then dilated with the 10mm balloon. Two guidewires, up to 0,035in. were inserted through separate ports. NAVIX device is then removed and plastic stents placed through the wires. Results: Nine patients with PFC were studied. Seven patients presented a pancreatic fluid collection in the setting of acute or chronic pancreatitis and two of them walled off pancreatic necrosis. Median age was 47 (range 10-63). The average collection size was 95 mm (range 43-150). Drainage of collections was feasible in all patients. The collections were accessed using a transgastric (7/9) or transduodenal (2/9) approach.Two pancreatic double pigtail stents were placed in eight patients, with diameters between 7F and 10F and length between 5 and 15cm. In one patient 3 double pigtail stents were placed (two 10F x 10 cm. and a 7F x 9 cm.) Resolution of the PFC was observed in 8/9 patients. In one patient an additional percutaneous retroperitoneal drain needed to be placed with favorable further evolution. No procedure related complications were observed. Discussion: Endoscopic drainage has emerged as the leading treatment modality for symptomatic pancreatic fluid collections over surgical or transabdominal treatments. NAVIX, a novel EUS guided single step access device provides a safe and effective endoscopic approach, as an alternative to more time and resources-consuming multi-step accesses. Sa1619 Temporary Endoscopic GES Effect on Gastric Emptying and Symptoms-Short and Long Term Results Thomas L. Abell* 1 , Jeffrey B. Mccrary 1 , Archana Kedar 1 , Christopher J. Lahr 2 , Yana Nikitina 1 , Andrew Q. Weeks 1 , Roland Maude-Griffin 3 , Warren Starkebaum 3 1 Digestive Diseases, University of Mississippi Medical Center, Jackson, MS; 2 Surgery, University of Mississippi Medical Center, Jackson, MS; 3 Medtronic, Inc., Minneapolis, MN Introduction: Temporary Endoscopic gastric electrical stimulation (tGES) is clinically useful for control of the symptoms of gastroparesis based on randomized and open label data. However, large sample size data is not available and the effect of GES on gastric emptying is unclear. We now report on a large series of consecutive patients treated with temporary and permanent GES who had well characterized GET evaluations.Patients: From a series of 551 consecutive patients, we analyzed 452 patients (42 rapid, 273 delayed, 137 normal) with complete baseline emptying data. We also compared GET of the patients with solid gastric emptying before and after temporary gastric electrical stimulation (GES). Methods: Temporary and permanent gastric stimulation was performed as previously reported (GIE 2005), irrespective of their baseline GET values. A sub analysis of gastric emptying was performed based on 123 normal controls analyzed for delayed normal or rapid solid radionuclide gastric emptying reported as 1, 2, 4 hours % remaining, area under the curve (AUC) and it’s surrogate of total GET. Gastrointestinal symptoms and gastric emptying were compared by Wilcoxon signed rank test and reported as mean and SE. Results: All patients symptoms improved irrespective of their baseline gastric emptying, with temporary stimulation, and effect maintained with permanent devices. Changes in symptoms under temporary GES were significantly correlated with changes in symptoms under permanent GES, with the strongest correlations being for the vomiting score (r=0.619, p0.0001) and TSS (r=0.501, p0.0001). Patients with the delayed emptying accelerated and those with rapid emptying slowed. (see table). Conclusions: Endoscopic temporary followed by permanent gastric electrical stimulation is an effective therapy for symptoms of gastroparesis, irrespective of baseline gastric emptying categories. The effect is rapid and sustained and disordered gastric emptying is modified. Temporary endoscopic followed by permanent gastric electrical stimulation is a significant therapy that warrants exploration in diagnoses other than traditional gastroparesis. Table 1. Gastric Retention [ mean %  SE] Baseline emptying class Treatment N 1st hour 2nd hour 4th hour GET total AUC Delayed Baseline 273 78  0.9 59 1.3 36  1.4 173  3.3 252  4.0 Temp GES 233 73  1.3* 53 1.6* 32  1.7† 159  4.3* 235  5.0* Normal Baseline 137 60  1.2 29 1.2 5  0.3 93 2.2 158  2.7 Temp GES 115 62  1.7 37 1.8** 15  1.5** 114 4.5** 183  5.3** Rapid Baseline 42 25  1.8 10  1.2 4  0.5 39  3.1 94  2.6 Temp GES 30 53 4.5** 28  3.9** 9  1.8†† 90  9.7** 153  11.5** †p0.05, ††p0.01, *p0.001, **p0.0001, vs baseline. Significance levels are from t-tests for differences in least squares means in repeated measures regression models for gastric emptying measurements and up from Wilcoxon signed-rank tests for changes in symptom scores from baseline Table 2. Symptom scores [median inter-quartile range] Figure 1. Navix device (left). It comprises a 19 G trocar capable to create a 3.5 mm incision for the balloon insertion. Endosonographic view (left) Figure 2. Once the access to the fluid collection is secured, dilation of the tract with the 10mm balloon is performed (left). Two stents up to 10F diameter can be placed through separated guidewires. Fluoroscopy view (left, right), endoscopic view (middle) Abstracts www.giejournal.org Volume 75, No. 4S : 2012 GASTROINTESTINAL ENDOSCOPY AB223