Author’s Accepted Manuscript PROBLEM-DRIVEN INNOVATIONS IN DRUG DISCOVERY: CO-EVOLUTION OF THE PATTERNS OF RADICAL INNOVATION WITH THE EVOLUTION OF PROBLEMS Mario Coccia PII: S2211-8837(16)00011-3 DOI: http://dx.doi.org/10.1016/j.hlpt.2016.02.003 Reference: HLPT172 To appear in: Health Policy and Technology Received date: 28 April 2015 Revised date: 20 October 2015 Accepted date: 8 February 2016 Cite this article as: Mario Coccia, PROBLEM-DRIVEN INNOVATIONS IN DRUG DISCOVERY: CO-EVOLUTION OF THE PATTERNS OF RADICAL INNOVATION WITH THE EVOLUTION OF PROBLEMS, Health Policy and Technology, http://dx.doi.org/10.1016/j.hlpt.2016.02.003 This is a PDF file of an unedited manuscript that has been accepted fo publication. As a service to our customers we are providing this early version o the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain www.elsevier.com/locate/hlpt