Pediatric Review - International Journal of Pediatric Research 2020 Volume 7 Number 4 April E-ISSN:2349-3267 P-ISSN:2349-5499 Research Article Diagnostic Publisher www.medresearch.in Diagnostic challenge: chronic bullous dermatosis of childhood Pasupathy U. 1* , Bhaskar N. 2 , Raghunathan J. 3 , Chidambaram S. 4 DOI: https://doi.org/10.17511/ijpr.2020.i04.05 1* Umapathy Pasupathy, Professor, Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. 2 Nithya Bhaskar, Junior Resident, Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. 3 Janani Raghunathan, Junior Resident, Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. 4 Sathya Chidambaram, Junior Resident, Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. Chronic bullous dermatosis of childhood is a rare acquired autoimmune disease characterized by subepidermal blistering disease of childhood with linear deposition of IGA on immunofluorescence. A 3-year-old female child presented with lesions mimicking Hand foot mouth disease which gradually progressed to isolated multiple bullous pruritic lesions all over the body. The absence of a characteristic string of pearl appearance, the histopathological findings, and the response to immunosuppressants lead us to the diagnosis of pox like lesions. Histopathology revealed parakeratosis with increased eosinophils. The child finally responded to a combination of cyclosporine and steroids. Although CBDC is common in lower trunk and genitalia it can also present as generalized bullous lesions. Here the current study reports a case of chronic bullous dermatosis of childhood that presented as a diagnostic challenge. Keywords: Chronic bullous dermatosis, Diagnostic challenge, Generalized bullae, Autoimmune Disease, IGA deposition, Parakeratosis Corresponding Author How to Cite this Article To Browse Umapathy Pasupathy, Professor, Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. Email: Pasupathy U, Bhaskar N, Raghunathan J, Chidambaram S. Diagnostic challenge: chronic bullous dermatosis of childhood. Pediatric Rev Int J Pediatr Res. 2020;7(4):190-193. Available From https://pediatrics.medresearch.in/index.php/ijpr/arti cle/view/584 Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted 2020-02-06 2020-02-17 2020-02-22 2020-02-28 Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note No Nil Yes 9% © 2020 by Umapathy Pasupathy, Nithya Bhaskar, Janani Raghunathan, Sathya Chidambaram and Published by Siddharth Health Research and Social Welfare Society. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0]. Pediatric Review - International Journal of Pediatric Research 2020 ;7 (4 ) 190