Journal of Basic and Applied Engineering Research Print ISSN: 2350-0077; Online ISSN: 2350-0255; Volume 1, Number 13; October-December 2014 pp. 70-73 © Krishi Sanskriti Publications http://www.krishisanskriti.org/jbaer.html Greener and Efficient Synthesis of Some Novel Substituted Azetidinones with 4-Amino Pyridine via γ-Ferrite as a Heterogenous Catalyst * Ritu Yadav 1 , Kalpana Avasthi 2 and Takallum Khan 3 1,2,3 Green-Synthetic Organic Laboratory, Department of Chemistry, Dr. Hari Singh Gour central University, SAGAR (M.P.) 470003, INDIA E-mail: 1 rituyadav1971@yahoo.co.in, 2 kalpana.avasthi@gmail.com Abstract—A new series of (3-chloro-2-oxo-4-substituted-Aryl-N- pyridine-4-yl-azetidinone) β –lactams (3a-3j) were synthesized via heterogenous catalysed reaction between 4 amino- pyridine and substituted aromatic benzaldehyde as a starting material by conventional in two steps. The structure of all the synthesized compounds were confirmed by chemical and spectral analysis such as IR,1H NMR,13C NMR and FAB-Mass. 1. INTRODUCTION Organic synthesis promoted by a solid heterogeneous catalyst have attracted wide spread interest and are advantageous because of operational simplicity, high selectivity, and clean separation of the product. Metal oxides has been recognized as a remarkably useful green heterogeneous catalyst to promote a wide range of organic reactions. 1 Herein we report a rapid and green approach to achieve highly substituted Azetidinones with pyridine in excellent yields in the presence of catalytic amount of γ-ferrite (Fe2O3) under controlled. Pyridine derivatives of different heterocyclic nucleus have shown very important pharmacological properties like antifungal 2-4 ,antitubercular 5 , antibacterial 6 , antimicrobial 7 , insecticidal 8 etc. Furthermore, different moieties of thiadiazole 9-10 , thiazolidinone 11-12 , and azetidinone 13-14 have also been reported to exhibit potent antifungal activities by several scientists. In the light of these observations, compounds of series.I were synthesized incorporating azetidinone moieties at 4-position of pyridine nucleus with a hope to develop better antifungal agents 15 . These compounds have been screened for their antifungal activity. 2-Azetidines have been extensively investigated by the organic chemists due to their close association with various types of biological activities 16 Azetidineones also have great importance because of the use of β-lactam derivatives as antibacterial agents. 2. MATERIALS AND METHODS All Melting points were taken in open glass capillaries and are uncorrected. Progress of the reaction was monitored by TLC on pre-coated Silica gel-aluminium plates (Type 60 F254, Merck, Darmstadt, Germany) in MeOH:CHCl3 system (1:9). The spot was visualized by exposing exposure to UV-light (254 nm) or dry plate in iodine vapours. The IR spectra were recorder on shimadzu FT-IR 8300 ( ν max in cm1) Spectrophotometer using (KBr disc) . 1 HNMR and 13 C-NMR spectra were measured on a JEOL DELTA-300 were spectrometer in DMSO-d6 at 300 MHz using TMS as an internal standard. Chemical shifts reported on δ scales. The FAB mass spectra were recorded on a JEOL SX-102 mass spectrometer. Elemental analyses were performed on a Carlo Erba-1108 analyser. The analytical data of all the compounds were highly satisfactory. For column chromatographic purification of the products, Merck silica Gel 60 (230-400 Mesh) was used. All chemicals were purchased from Sigma- Aldrich and the reagent grade chemicals were purchased from commercial sources and further purified before use. 2.1 General procedure for synthesis of Schiff bases compound ( 2a-2j) 4-Amino-pyridine (0.05 mol) was dissolved in 5 ml of ethanol in a 250 ml conical flask and was stirred at room temperature for 15 min to get a clear solution. To this solution, equimolar quantity (0.05 mol) of each substituted aryl aldehydes (in Ethanol) were added in presence of heterogenous catalyst γ- ferrite (Fe2O3) (in catalytic amount (0.01 mole%) and reaction mixture was refluxed with stirring up to 6–8 h at 70°C on magnetic stirrer. The reaction progress was monitored by TLC using mobile phase as chloroform: methanol (6:4).On completion of reaction, then allowed to cool. The product was purified over a column chromatography. The purified product was recrystallized from methanol at room temperature to give compound (2a-2j : Characterisation data of compounds (2a-2j) are presented below :